Department of Traditional Medicine, Faculty of Medicine, Shahed University, Tehran, Iran.
Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Altern Complement Med. 2020 May;26(5):398-408. doi: 10.1089/acm.2019.0254. Epub 2020 Feb 19.
The present study was conducted to investigate the effect of extracted syrup on the quality and patterns of sleep in patients with depression or obsessive-compulsive disorder (OCD) as add-on therapy. A pilot double-blind randomized placebo-controlled trial. Psychiatric Clinic of Imam Hossein Hospital, Tehran, Iran. Participants were 16-15 years of age with mild and moderate depression or OCD having insomnia. This pilot study was conducted on patients with insomnia divided into two groups with depression (40 patients) or OCD (43 patients). Each group randomly assigned into two arms with the same conditions at baseline. The intervention arm daily received 5 mL syrup every 12 h for 4 weeks, and the control arm received 5 mL placebo syrup every 12 h for 4 weeks. None of the participants was deprived of their routine treatment for depression or OCD. The scores of insomnia symptoms were evaluated using total score of the Pittsburgh Sleep Quality Index (PSQI) and the scores of its components, the depression score using the final Beck depression inventory-II (BDI-II) score, and OCD score using the Yale-Brown Obsessive-Compulsive Scale (YBOCS). The total PSQI score was found to be improved significantly in the intervention arms with depression or OCD ( < 0.001) compared with the corresponding control arms. Significant improvements were also observed in the final mean difference of BDI-II ( = 0.009) and YBOCS ( = 0.001) scores in the intervention arms. syrup significantly improved insomnia symptoms and the scores of depression and OCD.
本研究旨在探讨 提取糖浆作为附加疗法对抑郁症或强迫症（OCD）患者睡眠质量和模式的影响。一项双盲随机安慰剂对照试验的初步研究。伊朗德黑兰伊玛目侯赛因医院精神病学诊所。参与者为年龄在 16-15 岁之间、有失眠的轻度和中度抑郁症或 OCD 患者。这项初步研究对失眠患者进行了分组，分为抑郁症组（40 例）或 OCD 组（43 例）。每组患者在基线时随机分为两组，条件相同。干预组每天接受 5 毫升糖浆，每 12 小时一次，持续 4 周，对照组每 12 小时接受 5 毫升安慰剂糖浆，持续 4 周。两组患者均未剥夺常规治疗抑郁症或 OCD 的机会。使用匹兹堡睡眠质量指数（PSQI）总分和其各成分的评分评估失眠症状，使用贝克抑郁量表二（BDI-II）的最终评分评估抑郁程度，使用耶鲁-布朗强迫症量表（YBOCS）评估 OCD 程度。与相应的对照组相比，抑郁症或 OCD 患者的干预组 PSQI 总分明显改善（ < 0.001）。干预组的 BDI-II（ = 0.009）和 YBOCS（ = 0.001）评分的最终平均差异也有显著改善。
