提取物治疗失眠的疗效：一项系统评价与荟萃分析
The Efficacy of Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis.
作者信息
Huang Shuangfeng, Huang Qianqian, Zhou Zhongbao, Zhang Junliang, Zhan Yan, Liang Zhigang
机构信息
The Second Clinical Medical College, Binzhou Medical University, Yantai, China.
Department of Gastroenterology, People's Hospital of Jimo District, Qingdao, China.
出版信息
Front Neurol. 2022 Jun 6;13:730311. doi: 10.3389/fneur.2022.730311. eCollection 2022.
AIM
This systematic review and meta-analysis was performed to assess the effect of () extract in the treatment of insomnia.
METHODS
PubMed, EMBASE, and Cochrane Library databases, as well as references of related articles, were searched. Finally, four articles with five clinical trials including 224 patients were included in the analysis.
RESULTS
The obtained results indicated a greater improvement in total PSQI scores (MD,-4.67; = 0.0002), subjective sleep quality score (MD,-0.91; = 0.003), sleep duration score (MD,-0.77; < 0.00001), and ISI score (MD,-6.30; = 0.009) in the Viola extract group compared with the placebo group. However, the Viola extract group did not significantly differ in sleep latency (MD,-0.85; = 0.08), habitual sleep efficiency (MD,-0.61; = 0.21), sleep disturbances (MD,-0.36; = 0.11), and daytime dysfunction (MD,-0.94; = 0.12) from the placebo group.
CONCLUSIONS
extract supplement led to a greater improvement in total PSQI scores, subjective sleep quality score, sleep duration score, and ISI score compared with the placebo group of patients with chronic insomnia.
目的
进行本系统评价和荟萃分析以评估（）提取物治疗失眠的效果。
方法
检索了PubMed、EMBASE和Cochrane图书馆数据库以及相关文章的参考文献。最终，纳入分析的有4篇文章，包含5项临床试验，共224例患者。
结果
获得的结果表明，与安慰剂组相比，堇菜提取物组在总匹兹堡睡眠质量指数（PSQI）评分（MD，-4.67；P = 0.0002）、主观睡眠质量评分（MD，-0.91；P = 0.003）、睡眠时间评分（MD，-0.77；P < 0.00001）和失眠严重指数（ISI）评分（MD，-6.30；P = 0.009）方面有更大改善。然而，堇菜提取物组与安慰剂组在睡眠潜伏期（MD，-0.85；P = 0.08）、习惯性睡眠效率（MD，-0.61；P = 0.21）、睡眠障碍（MD，-0.36；P = 0.11）和日间功能障碍（MD，-0.94；P = 0.12）方面无显著差异。
结论
与慢性失眠患者的安慰剂组相比，（）提取物补充剂在总PSQI评分、主观睡眠质量评分、睡眠时间评分和ISI评分方面有更大改善。
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