Kolb Logan J, Ellis Carolyn, Lafond Ann
Department of Dermatology, Orange Park Medical Center, Florida, USA.
Department of Dermatology, St. Joseph Mercy Hospital, Ann Arbor, Michigan, USA.
Cutis. 2020 Jan;105(1):E11-E14.
Calciphylaxis is a potentially fatal disease caused by metastatic calcification of the small- and medium-sized blood vessels of the dermis and subcutis. It most commonly is seen in patients with renal disease requiring dialysis, but it also may be triggered by nonuremic causes in patients with known risk factors for calciphylaxis. We report a case of nonuremic calciphylaxis (NUC) occurring in the setting of multiple risk factors, including chronic corticosteroid use, obesity, rapid weight loss, and hypotension. A review of the literature also is provided with an in-depth discussion of the known risk factors and triggers of NUC.
钙过敏是一种由真皮和皮下组织中小血管转移性钙化引起的潜在致命疾病。它最常见于需要透析的肾病患者，但在已知有钙过敏风险因素的患者中，也可能由非尿毒症原因引发。我们报告一例在多种风险因素背景下发生的非尿毒症性钙过敏（NUC）病例，这些风险因素包括长期使用皮质类固醇、肥胖、快速体重减轻和低血压。本文还对文献进行了综述，并深入讨论了已知的NUC风险因素和触发因素。
