Iyoho Anthony E, Ho Kevin, Chan Philemon
L-3 Applied Technologies Inc., 10180 Barnes Canyon Road, San Diego, CA 92121.
Mil Med. 2020 Jan 7;185(Suppl 1):234-242. doi: 10.1093/milmed/usz215.
There is no dose-response model available for the assessment of the risk of tympanic membrane rupture (TMR), commonly known as eardrum rupture, from exposures to blast from nonlethal flashbangs, which can occur concurrently with temporary threshold shift. Therefore, the objective of this work was to develop a fast-running, lumped parameter model of the tympanic membrane (TM) with probabilistic dose-dependent prediction of injury risk.
The lumped parameter model was first benchmarked with a finite element model of the middle ear. To develop the dose-response curves, TMR data from a historic cadaver study were utilized. From these data, the binary probability response was constructed and logistic regression was applied to generate the respective dose-response curves at moderate and severe eardrum rupture severity.
Hosmer-Lemeshow statistical and receiver operation characteristic analyses showed that maximum stored TM energy was the overall best dose metric or injury correlate when compared with total work and peak TM pressure.
Dose-response curves are needed for probabilistic risk assessments of unintended effects like TMR. For increased functionality, the lumped parameter model was packaged as a software library that predicts eardrum rupture for a given blast loading condition.
对于评估因暴露于非致命闪光震撼弹爆炸而导致鼓膜破裂（TMR，俗称耳膜破裂）的风险，目前尚无剂量反应模型，这种爆炸可能与暂时性阈移同时发生。因此，本研究的目的是建立一个运行快速的鼓膜（TM）集总参数模型，对损伤风险进行概率性剂量依赖性预测。
该集总参数模型首先与中耳的有限元模型进行了基准测试。为了绘制剂量反应曲线，利用了一项历史尸体研究中的TMR数据。从这些数据中构建了二元概率反应，并应用逻辑回归生成了中度和重度耳膜破裂严重程度下各自的剂量反应曲线。
与总功和鼓膜峰值压力相比，霍斯默-莱梅肖统计分析和受试者工作特征分析表明，最大储存的鼓膜能量是总体上最佳的剂量指标或损伤关联指标。
对于鼓膜破裂等意外效应的概率风险评估，需要剂量反应曲线。为了增加功能，集总参数模型被打包为一个软件库，可预测给定爆炸载荷条件下的耳膜破裂情况。
