Brahmajothi Mulugu V, Abou-Donia Mohamed B
Department of Pharmacology and Cancer Biology, Duke University Medical Center, PO Box 3813, Durham, NC 27710.
Mil Med. 2020 Jan 7;185(Suppl 1):197-204. doi: 10.1093/milmed/usz301.
Serum repositories are foundations for seroepidemiological data, revealing targeted information about morbidities and existing heterogeneity in human populations. With the recent technological advances, we can perform high-throughput screening at an affordable cost using minimal plasma. Monitoring brain health after an injury is critical since mild Traumatic Brain Injury (mTBI) and other neurological symptoms are under-diagnosed. Our objective in this study is to present our preliminary serological data from one of our ongoing studies on mTBI.
In this retrospective study, we used stored plasma samples to understand biomarkers of mTBI. We compared plasma samples from five patients with mTBI following their first concussive episode to five gender and age-matched healthy controls. We assessed multiple biomarkers to show the importance of biorepositories.
Most of the estimated plasma factors in mTBI subjects at baseline were comparable to normal healthy individuals except for the astroglial markers S100B and glial fibrillary acidic protein. Fluctuations of these biomarkers can affect the homeostasis of brain parenchyma by altering the neural network signaling, which in turn may result in intermittent behavioral symptoms.
Biorepositories are powerful resources for understanding the spectrum of morbidity. Biomarkers serve as a valuable diagnostic and therapeutic tool.
血清库是血清流行病学数据的基础，可揭示有关人群发病率和现有异质性的目标信息。随着最近技术的进步，我们能够以可承受的成本使用极少的血浆进行高通量筛查。在受伤后监测脑部健康至关重要，因为轻度创伤性脑损伤（mTBI）和其他神经症状未得到充分诊断。我们在本研究中的目的是展示我们正在进行的一项关于mTBI研究的初步血清学数据。
在这项回顾性研究中，我们使用储存的血浆样本了解mTBI的生物标志物。我们将五名mTBI患者首次脑震荡发作后的血浆样本与五名年龄和性别匹配的健康对照进行了比较。我们评估了多种生物标志物以显示生物样本库的重要性。
除星形胶质细胞标志物S100B和胶质纤维酸性蛋白外，mTBI受试者基线时大多数估计的血浆因子与正常健康个体相当。这些生物标志物的波动可通过改变神经网络信号影响脑实质的稳态，进而可能导致间歇性行为症状。
生物样本库是了解发病谱的强大资源。生物标志物是有价值的诊断和治疗工具。
