Li J F, Zhu Z G, Liu B Y
Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai 200025, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Feb 25;23(2):140-143. doi: 10.3760/cma.j.issn.1671-0274.2020.02.008.
Translational medicine refers to translating basic research achievements into the clinical application for diagnosis and treatment. There are still many issues of gastric cancer to be solved in clinical diagnosis and treatment. We need to focus on clinical questions, by means of basic research and multidisciplinary intersection approach, to further improve the overall efficacy of gastric cancer. Based on Ruijin Hospital's translational research experiences, in this paper, the authors describe the future direction in the field of translational research, such as the etiology and pathogenesis of gastric cancer, tumor markers for early diagnosis, prediction of recurrence and metastasis, classification criteria, evaluation of chemotherapy, tumor heterogeneity, targeted therapy, immunotherapy and research platform establishment. In addition, here we share our perspective of the research on serum biomarkers, specific antibodies and improvement of drug delivery for gastric cancer.
转化医学是指将基础研究成果转化为临床诊断和治疗应用。胃癌的临床诊断和治疗仍有许多问题有待解决。我们需要聚焦临床问题，借助基础研究和多学科交叉方法，进一步提高胃癌的整体疗效。基于瑞金医院的转化研究经验，本文作者阐述了转化研究领域的未来方向，如胃癌的病因和发病机制、早期诊断的肿瘤标志物、复发和转移的预测、分类标准、化疗评估、肿瘤异质性、靶向治疗、免疫治疗以及研究平台的建立。此外，在此我们分享我们对胃癌血清生物标志物、特异性抗体及药物递送改进研究的观点。
