Department of Information Engineering, Electronics and Telecommunications (DIET), University of Rome "La Sapienza", Rome, Italy.
Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
Sci Rep. 2020 Feb 19;10(1):2945. doi: 10.1038/s41598-020-59471-9.
Neuroprotective effects of pulsed electromagnetic fields (PEMFs) have been demonstrated both in vivo and in vitro. Moreover, preliminary clinical studies have been conducted and suggested PEMFs as a possible alternative therapy to treat acute ischemic stroke. In this work, we show that it's possible to build-up a patient semi-specific head model, where the 3D reconstruction of the ischemic lesion of the patient under treatment is inserted in the head of the human body model "Duke" (v.1.0, Zurich MedTech AG). The semi-specific model will be used in the randomized, placebo-controlled, double-blind study currently ongoing. Three patients were modelled and simulated, and results showed that each ischemic lesion experiences a magnetic flux density field comparable to the one for which biological effects have been attested. Such a kind of dosimetric analysis reveals a reliable tool to assess the correlation between levels of exposure and the beneficial effect. Thus, once the on-going double blind study is complete it will prove if PEMFs treatment triggers a clinical effect, and we will then be able to characterize a dose-response curve with the methodology arranged in this study.
脉冲电磁场（PEMFs）的神经保护作用已在体内和体外得到证实。此外，已经进行了初步的临床研究，并提出 PEMFs 作为治疗急性缺血性中风的一种可能的替代疗法。在这项工作中，我们展示了构建患者半特异性头部模型的可能性，其中将治疗下患者的缺血性病变的 3D 重建插入到人体模型“Duke”（v.1.0，Zurich MedTech AG）的头部。半特异性模型将用于目前正在进行的随机、安慰剂对照、双盲研究。对三名患者进行了建模和模拟，结果表明，每个缺血性病变都经历了与已证明具有生物效应的磁场强度相当的磁场强度。这种剂量分析揭示了一种可靠的工具，可以评估暴露水平与有益效果之间的相关性。因此，一旦正在进行的双盲研究完成，它将证明 PEMFs 治疗是否引发临床效果，然后我们将能够用本研究中安排的方法来描述剂量反应曲线。
