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自动定量提取和分析升主动脉中的 4D 流型：1.5T 和 3T 下的个体内比较。

Automated Quantitative Extraction and Analysis of 4D flow Patterns in the Ascending Aorta: An intraindividual comparison at 1.5 T and 3 T.

机构信息

Department of Diagnostic and Interventional Radiology, University of Leipzig - Heart Centre, Leipzig, Germany.

Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.

出版信息

Sci Rep. 2020 Feb 19;10(1):2949. doi: 10.1038/s41598-020-59826-2.

DOI:10.1038/s41598-020-59826-2
PMID:32076060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7031260/
Abstract

4D flow MRI enables quantitative assessment of helical flow. Current methods are susceptible to noise. To evaluate helical flow patterns in healthy volunteers and patients with bicuspid aortic valves (BAV) at 1.5 T and 3 T using pressure-based helix-extraction in 4D flow MRI. Two intraindividual 4D flow MRI examinations were performed at 1.5 T and 3 T in ten healthy volunteers (5 females, 32 ± 3 years) and 2 patients with BAV using different acceleration techniques (kt-GRAPPA and centra). Several new quantitative parameters for the evaluation of volumes [ml], lengths [mm] as well as temporal parameters [ms] of helical flow were introduced and analyzed using the software tool Bloodline. We found good correlations between measurements in volunteers at 1.5 T and 3 T regarding helical flow volumes (R = 0.98) and temporal existence (R = 0.99) of helices in the ascending aorta. Furthermore, we found significantly larger (11.7 vs. 77.6 ml) and longer lasting (317 vs. 769 ms) helices in patients with BAV than in volunteers. The assessed parameters do not depend on the magnetic field strength used for the acquisition. The technique of pressure-based extraction of 4D flow MRI pattern is suitable for differentiation of normal and pathological flow.

摘要

4D flow MRI 能够定量评估螺旋流。目前的方法容易受到噪声的影响。本研究旨在使用基于压力的 4D flow MRI 螺旋提取方法，在 1.5T 和 3T 下评估健康志愿者和二叶式主动脉瓣（BAV）患者的螺旋流动模式。在 1.5T 和 3T 下，使用不同的加速技术（kt-GRAPPA 和 centra）对 10 名健康志愿者（5 名女性，32±3 岁）和 2 名 BAV 患者进行了两次个体内 4D flow MRI 检查。使用 Bloodline 软件工具，引入了几个新的定量参数来评估螺旋流的体积[ml]、长度[mm]和时间参数[ms]。我们发现志愿者在 1.5T 和 3T 下的螺旋流体积（R=0.98）和升主动脉中螺旋存在的时间（R=0.99）的测量值之间存在良好的相关性。此外，我们发现 BAV 患者的螺旋流体积（11.7 vs. 77.6ml）和持续时间（317 vs. 769ms）明显大于志愿者。所评估的参数不依赖于采集时使用的磁场强度。基于压力的 4D flow MRI 模式提取技术适合于正常和病理血流的区分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/2ba2d6eee460/41598_2020_59826_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/0165a99b89a6/41598_2020_59826_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/a031c88f629f/41598_2020_59826_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/bcf48c3370e1/41598_2020_59826_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/a785c4ab4eed/41598_2020_59826_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/d202919d2231/41598_2020_59826_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/39b3434adf3d/41598_2020_59826_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/541b0773ad40/41598_2020_59826_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/2ba2d6eee460/41598_2020_59826_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/0165a99b89a6/41598_2020_59826_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/a031c88f629f/41598_2020_59826_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/bcf48c3370e1/41598_2020_59826_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/a785c4ab4eed/41598_2020_59826_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/d202919d2231/41598_2020_59826_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/39b3434adf3d/41598_2020_59826_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/541b0773ad40/41598_2020_59826_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778d/7031260/2ba2d6eee460/41598_2020_59826_Fig8_HTML.jpg

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