Oudjehih Messaouda, Deltour Isabelle, Bouhidel Mohamed Larbi, Bouhidel Atika, Marref Abdelwahab, Luzon Véronique, Schüz Joachim, Bouneceur Hocine, Leon Maria E
Medical Faculty, Epidemiology and Preventive Medicine Department, University of Batna, Batna, Algeria.
Cancer Registry of the Wilaya of Batna, University Hospital of Batna, Batna, Algeria.
Tob Use Insights. 2020 Feb 5;13:1179173X20902239. doi: 10.1177/1179173X20902239. eCollection 2020.
A significant proportion of the Algerian population uses tobacco products and is at risk of developing tobacco-associated cancers.
This case-control study reports on the association between tobacco use and the occurrence of upper aerodigestive tract (UADT) cancers in Batna, Algeria.
Incident primary UADT cancer cases in residents of Batna in 2008-2011 were identified using the regional tumor registry. One hospital and 1 population control were matched to each case by sex, year of birth, and residence. Information on tobacco use was collected, and odds ratios (ORs) were obtained using conditional logistic regression also after sex stratification.
The study included 192 cases (80%) of the 241 primary UADT cancer cases identified and 384 controls. Males represented 76.6% of cancer cases. Cancers of the nasopharynx (48%) and the larynx (26%) were the most common types. Ever use of smokeless tobacco (ST) (OR = 1.0; 95% confidence interval [CI]: 0.6-1.5) or current ST use (OR = 1.1; 95% CI: 0.6-1.7) was not associated with overall risk of UADT cancers. Associations with cancers of the nasopharynx (OR = 1.5; 95% CI: 0.5-4.6) and oral cavity/oropharynx (OR = 3.0; 95% CI: 0.8-11.8) were found when comparing use of ST only to no consumption of any tobacco. Cigarette smoking was associated with an increase in the overall risk of UADT cancers, with a 3-fold increase in the risk of laryngeal cancer when comparing smoking only to no consumption of any tobacco (OR = 3.3; 95% CI: 1.0-11.5). Associations for smokers who also consumed ST differed by cancer site.
In this study from Algeria dominated by male cases and by cancer in the nasopharynx, cigarette smoking but not ST was associated with UADT cancer. Analyses by anatomical site and using as reference never use of any type of tobacco suggested few associations with ST but of lower precision.
很大一部分阿尔及利亚人口使用烟草制品，面临罹患烟草相关癌症的风险。
本病例对照研究报告了阿尔及利亚巴特纳地区烟草使用与上呼吸道消化道（UADT）癌症发生之间的关联。
利用地区肿瘤登记处确定了2008 - 2011年巴特纳居民中首次发生的原发性UADT癌症病例。按照性别、出生年份和居住地为每个病例匹配1名医院对照和1名人群对照。收集了烟草使用信息，并在按性别分层后使用条件逻辑回归获得比值比（OR）。
该研究纳入了241例已确定的原发性UADT癌症病例中的192例（80%）以及384名对照。男性占癌症病例的76.6%。鼻咽癌（48%）和喉癌（26%）是最常见的类型。曾经使用无烟烟草（ST）（OR = 1.0；95%置信区间[CI]：0.6 - 1.5）或当前使用ST（OR = 1.1；95% CI：0.6 - 1.7）与UADT癌症的总体风险无关。仅将ST使用情况与不使用任何烟草进行比较时，发现与鼻咽癌（OR = 1.5；95% CI：0.5 - 4.6）和口腔/口咽癌（OR = 3.0；95% CI：0.8 - 11.8）有关联。吸烟与UADT癌症总体风险增加有关，仅将吸烟情况与不使用任何烟草进行比较时，喉癌风险增加3倍（OR = 3.3；95% CI：1.0 - 11.5）。同时使用ST的吸烟者的关联因癌症部位而异。
在这项以男性病例和鼻咽癌为主的阿尔及利亚研究中，吸烟而非ST使用与UADT癌症有关。按解剖部位进行分析并以从不使用任何类型烟草作为对照，结果显示与ST的关联较少且精确度较低。
