Lundsgaard-Hansen P
Vox Sang. 1977;32(1):20-5. doi: 10.1111/j.1423-0410.1977.tb00599.x.
The published specifications of the acceptable limits of the maximum plasma volume to be "harvested" by plasmapheresis from one individual per year vary from 10-15 liters in Europe to 50-60 liters in the United States. To answer the question which of these widely diverging precepts is appropriate, the effects of plasmapheresis on serum protein levels and their relationship to albumin metabolism, the accepted safeguards for the donation of whole blood, and the disease known as the nephrotic syndrome are considered. A living person who cosents to his bodily integrity being violated for the benefit of others must be protected not only against the generation of manifest illness by such violation, but also against any prolonged deviation from the normal state of his body. It is concluded that plasmapheresis donors should not deliver more than 10 to 15 liters of plasma per year, as now recommended by European authorities. Not more than 500 ml of plasma should be withdrawn per session, and the interval between two such sessions should not be less than 2 weeks.
血浆置换法每年从一个人身上“采集”的最大血浆量的可接受限度，其已公布的规范在欧洲为10至15升，在美国则为50至60升。为了回答这些差异巨大的规范中哪一个是合适的问题，我们考虑了血浆置换对血清蛋白水平的影响及其与白蛋白代谢的关系、全血捐献的公认保障措施以及被称为肾病综合征的疾病。一个同意为他人利益而使其身体完整性受到侵犯的活人，不仅必须受到保护，以免因这种侵犯而产生明显疾病，而且还必须防止其身体长期偏离正常状态。结论是，血浆置换捐献者每年不应捐献超过10至15升血浆，正如欧洲当局目前所建议的那样。每次不应抽取超过500毫升血浆，且两次这样的抽取之间的间隔不应少于2周。
