Anssari Neda, Vosoughi Reza, Mullen Kathy, Mansouri Behzad
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.
Section of Neurology, Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Neuroophthalmology. 2019 Jun 19;44(1):16-23. doi: 10.1080/01658107.2019.1615960. eCollection 2020 Feb.
Multiple sclerosis (MS) without optic neuritis causes color-vision deficit but the evidence for selective color deficits in parvocellular-Red/Green (PC-RG) and koniocellular-Blue/Yellow (KC-BY) pathways is inconclusive. We investigated selective color-vision deficits at different MS stages. Thirty-one MS and twenty normal participants were tested for achromatic, red-green and blue-yellow sinewave-gratings (0.5 and 2 cycles-per-degree (cpd)) contrast orientation discrimination threshold. Red-green mean threshold at 0.5cpd in established-MS and blue-yellow mean threshold in all MS participants were abnormal. These findings show blue-yellow versus red-green color test is useful in differentiating MS chronicity, which helps to better understand the mechanism of colour-vision involvement in MS.
无视神经炎的多发性硬化症（MS）会导致色觉缺陷，但关于小细胞红/绿（PC-RG）和侏儒细胞蓝/黄（KC-BY）通路中选择性色觉缺陷的证据尚无定论。我们研究了MS不同阶段的选择性色觉缺陷。对31名MS患者和20名正常参与者进行了无彩色、红-绿和蓝-黄正弦波光栅（0.5和2周/度（cpd））对比度方向辨别阈值测试。确诊MS患者在0.5 cpd时的红-绿平均阈值以及所有MS参与者的蓝-黄平均阈值均异常。这些发现表明，蓝-黄与红-绿颜色测试有助于区分MS的病程，这有助于更好地理解MS中色觉受累的机制。
