Jin Haochen, Yu Xi, Cao Suqi, Wang Mengting, Hu Xiaozhou, Ye Jie, Liu Weijie, Xu Mingna, Wu Wencan, Tu Yunhai
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Front Neurosci. 2022 Sep 21;16:990425. doi: 10.3389/fnins.2022.990425. eCollection 2022.
We explored whether thyroid-associated ophthalmopathy (TAO) patients without clinical signs of dysthyroid optic neuropathy (DON) would have a selective deficit mediated by S-cone.
Thirty-two TAO patients without clinical signs of DON (non-DON, 42.03 ± 9.59 years old) and 27 healthy controls (41.46 ± 6.72 years old) participated in this prospective, cross-sectional study. All observers were tested psychophysically after passing color screening tests and a comprehensive ocular examination. Isolated L-, M-, and S-cone contrast thresholds were measured at 0.5 cyc/deg using Gabor patches. We calculated the area under the receiver operating characteristic (ROC) curve to quantify the ability of chromatic contrast sensitivity to detect the early visual function changes in non-DON patients.
S-cone contrast sensitivity in non-DON patients was found to be lower than that of healthy controls ( < 0.001), whereas the sensitivities to L- and M-cone Gabor patches were similar between these two groups ( = 0.297, 0.666, respectively). Our analysis of the ROC curve revealed that the sensitivity to S-cone had the highest index to discriminate non-DON patients from healthy controls (AUC = 0.846, < 0.001). The deficit of S-cone was significantly correlated with muscle index in non-DON patients ( = 0.576, = 0.001).
There is a selective S-cone deficit in the early stage of TAO. S-cone contrast sensitivity could serve as a sensitive measure of visual impairments associated with early DON in patients with TAO.
我们探讨了无甲状腺功能异常性视神经病变（DON）临床体征的甲状腺相关眼病（TAO）患者是否存在由S视锥细胞介导的选择性缺陷。
32例无DON临床体征的TAO患者（非DON组，42.03±9.59岁）和27名健康对照者（41.46±6.72岁）参与了这项前瞻性横断面研究。所有观察者在通过颜色筛查测试和全面的眼部检查后进行了心理物理学测试。使用Gabor斑块在0.5周/度测量孤立的L、M和S视锥细胞对比阈值。我们计算了受试者工作特征（ROC）曲线下的面积，以量化色觉对比敏感度检测非DON患者早期视觉功能变化的能力。
发现非DON患者的S视锥细胞对比敏感度低于健康对照者（<0.001），而两组之间对L和M视锥细胞Gabor斑块的敏感度相似（分别为=0.297，0.666）。我们对ROC曲线的分析表明，对S视锥细胞的敏感度在区分非DON患者和健康对照者方面具有最高指数（AUC=0.846，<0.001）。非DON患者中S视锥细胞的缺陷与肌肉指数显著相关（=0.576，=0.001）。
TAO早期存在选择性S视锥细胞缺陷。S视锥细胞对比敏感度可作为TAO患者早期DON相关视觉损害的敏感指标。
