血清尿酸浓度及其变化与心血管死亡和全因死亡率的关系。
Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality.
机构信息
Shanxi Medical University, Jinzhong, 030600 Shanxi, China.
Department of Nephrology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 Hubei, China.
出版信息
Dis Markers. 2020 Jan 28;2020:7646384. doi: 10.1155/2020/7646384. eCollection 2020.
OBJECTIVE
There is no consensus on the role of abnormal uric acid (UA) levels in the prognosis of patients undergoing hemodialysis. We therefore aimed to investigate the effects of changes in UA concentration on the risk of all-cause death and cardiac death in such patients.
METHOD
In this retrospective cohort study, patients admitted to two hemodialysis centers performing maintenance hemodialysis (MHD) in Wuhan First Hospital and Fourth Hospital Hemodialysis Center from January 1, 2007, to October 31, 2017, were included.
RESULTS
In all, 325 patients undergoing MHD aged 59.7 ± 14.7 years, including 195 men (60%), were enrolled, with a median follow-up of 37 months. Serum UA ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability ( < 0.001) was significantly higher in the surviving group than in the death group. No significant difference was found in UA variability (.
CONCLUSION
Low UA levels were closely related to all-cause mortality in patients undergoing MHD. Although UA levels had no significant effect on cardiac death, they had a good predictive value for long-term prognosis in patients on MHD.
目的
尿酸（UA）水平异常在接受血液透析患者的预后中的作用尚未达成共识。因此，本研究旨在探讨 UA 浓度变化对这些患者全因死亡和心脏死亡风险的影响。
方法
这是一项回顾性队列研究，纳入了 2007 年 1 月 1 日至 2017 年 10 月 31 日期间在武汉第一医院和第四医院血液透析中心接受维持性血液透析（MHD）的患者。
结果
共纳入 325 名年龄为 59.7±14.7 岁的 MHD 患者（男性 195 名，占 60%），中位随访时间为 37 个月。存活组的血清 UA 显著高于死亡组（<0.001）。UA 变异性在存活组和死亡组之间无显著差异（<0.001）。
结论
低 UA 水平与 MHD 患者的全因死亡率密切相关。虽然 UA 水平对心脏死亡没有显著影响，但对 MHD 患者的长期预后具有良好的预测价值。
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