Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
State Key Laboratory of Oral Disease, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610064, China.
Biomed Res Int. 2020 Jan 31;2020:5658212. doi: 10.1155/2020/5658212. eCollection 2020.
Dental caries is the most common oral disease. The bacteriological aetiology of dental caries promotes the use of antibiotics or antimicrobial agents to prevent this type of oral infectious disease. Antibiotics have been developed for more than 80 years since Fleming discovered penicillin in 1928, and systemic antibiotics have been used to treat dental caries for a long time. However, new types of antimicrobial agents have been developed to fight against dental caries. The purpose of this review is to focus on the application of systemic antibiotics and other antimicrobial agents with respect to their clinical use to date, including the history of their development, and their side effects, uses, structure types, and molecular mechanisms to promote a better understanding of the importance of microbial interactions in dental plaque and combinational treatments.
龋齿是最常见的口腔疾病。龋齿的细菌病因学促进了抗生素或抗菌剂的使用，以预防这种类型的口腔传染病。自弗莱明于 1928 年发现青霉素以来，抗生素已经发展了 80 多年，并且长期以来一直使用全身抗生素来治疗龋齿。然而，已经开发出新型的抗菌剂来对抗龋齿。本综述的目的是重点关注全身抗生素和其他抗菌剂的临床应用，包括它们的发展历史、副作用、用途、结构类型和分子机制，以促进更好地理解微生物相互作用在牙菌斑中的重要性和联合治疗。
