Odeh Dana M, Odeh Mohanad M, Hafez Taghrid S, Hassan Ashraf S
Department of Pharmacy, Faculty of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, Jordan.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
Molecules. 2025 Jan 17;30(2):366. doi: 10.3390/molecules30020366.
Heterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable and diverse biological properties. The 5-aminopyrazole derivatives are key starting materials for the synthesis of numerous bioactive compounds such as pyrazolopyridine, pyrazolopyrimidine, pyrazoloquinazoline, and pyrazolotriazine derivatives. Many compounds inspired by the 5-aminopyrazole derivatives possess a wide spectrum of biological activities and medicinal applications such as antioxidants, anticancer agents, enzyme inhibitors, antimicrobials, and anti-tuberculosis activities. This review summarizes the recently reported synthesis methods and biological activities of fused pyrazole and pyrazole-based derivatives based on 5-aminopyrazole compounds within the last 5 years (2020 to present). One of the important goals of this review is to illustrate future strategies for the design, development, and utilization of pyrazole products as potent drugs.
杂环化合物，尤其是那些含有吡唑部分的化合物，在有机化学中具有高度重要性，并具有显著且多样的生物学特性。5-氨基吡唑衍生物是合成众多生物活性化合物的关键起始原料，如吡唑并吡啶、吡唑并嘧啶、吡唑并喹唑啉和吡唑并三嗪衍生物。许多受5-氨基吡唑衍生物启发的化合物具有广泛的生物活性和药用应用，如抗氧化剂、抗癌剂、酶抑制剂、抗菌剂和抗结核活性。本综述总结了过去5年（2020年至今）基于5-氨基吡唑化合物的稠合吡唑和吡唑基衍生物的最新报道合成方法和生物活性。本综述的一个重要目标是阐述将吡唑产品设计、开发和用作有效药物的未来策略。
