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Could stress ulcer prophylaxis increase mortality in high-acuity patients?

作者信息

Harhay Michael O, Young Paul J, Shankar-Hari Manu

机构信息

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, 304 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA.

Palliative and Advanced Illness Research (PAIR) Center and Pulmonary and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Intensive Care Med. 2020 Apr;46(4):793-795. doi: 10.1007/s00134-020-05959-x. Epub 2020 Feb 19.

DOI:10.1007/s00134-020-05959-x
PMID:32076767
Abstract
摘要

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2
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[Bleeding and pneumonia in intensive care unit patients given proton pump inhibitor or histamine-2 receptor antagonist for prevention of stress ulcer: a Meta analysis].[在重症监护病房患者中使用质子泵抑制剂或组胺-2受体拮抗剂预防应激性溃疡时的出血和肺炎：一项Meta分析]
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Crit Care Med. 2014 Apr;42(4):809-15. doi: 10.1097/CCM.0000000000000032.
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Time to declare a moratorium on stress ulcer prophylaxis in critically ill.是时候宣布对危重症患者预防性使用应激性溃疡药物予以暂停了。
Crit Care Med. 2014 Sep;42(9):e636-7. doi: 10.1097/CCM.0000000000000471.
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Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.质子泵抑制剂与组胺 2 受体拮抗剂预防应激性溃疡对接受有创机械通气的 ICU 患者院内死亡率的影响：PEPTIC 随机临床试验。
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Syst Rev. 2017 Jun 24;6(1):118. doi: 10.1186/s13643-017-0509-4.
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Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients.医院获得性肺炎风险与应激性溃疡预防：泮托拉唑与雷尼替丁在心胸外科手术患者中的比较
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本文引用的文献

1
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.质子泵抑制剂与组胺 2 受体拮抗剂预防应激性溃疡对接受有创机械通气的 ICU 患者院内死亡率的影响：PEPTIC 随机临床试验。
JAMA. 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190.
2
Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial.成年 ICU 患者预防性使用泮托拉唑的治疗效果的异质性：SUP-ICU 试验的事后分析。
Intensive Care Med. 2020 Apr;46(4):717-726. doi: 10.1007/s00134-019-05903-8. Epub 2020 Jan 14.
3
Opportunities and challenges of clustering, crossing over, and using registry data in the PEPTIC trial.
在消化性溃疡试验中进行聚类、交叉以及使用注册数据的机遇与挑战。
Crit Care Resusc. 2020 Jun;22(2):105-109. doi: 10.51893/2020.2.ed2.
Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis.
危重症患者胃肠出血预防的疗效和安全性：系统评价和网络荟萃分析。
BMJ. 2020 Jan 6;368:l6744. doi: 10.1136/bmj.l6744.
4
Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial.重症监护病房高疾病严重程度患者的泮托拉唑预防：安慰剂对照 SUP-ICU 试验的事后分析。
Intensive Care Med. 2019 May;45(5):609-618. doi: 10.1007/s00134-019-05589-y. Epub 2019 Mar 12.
5
Personalized evidence based medicine: predictive approaches to heterogeneous treatment effects.个体化循证医学：预测异质性治疗效果的方法。
BMJ. 2018 Dec 10;363:k4245. doi: 10.1136/bmj.k4245.
6
Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU.重症监护病房有胃肠道出血风险的患者使用泮托拉唑。
N Engl J Med. 2018 Dec 6;379(23):2199-2208. doi: 10.1056/NEJMoa1714919. Epub 2018 Oct 24.
7
Using group data to treat individuals: understanding heterogeneous treatment effects in the age of precision medicine and patient-centred evidence.使用群体数据治疗个体：在精准医学和以患者为中心的证据时代理解异质性治疗效果。
Int J Epidemiol. 2016 Dec 1;45(6):2184-2193. doi: 10.1093/ije/dyw125.
8
Three simple rules to ensure reasonably credible subgroup analyses.确保亚组分析具有合理可信度的三条简单规则。
BMJ. 2015 Nov 4;351:h5651. doi: 10.1136/bmj.h5651.
9
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients.急性危重病成年重症监护患者的胃肠道出血发生率和结局以及抑酸剂的使用情况。
Intensive Care Med. 2015 May;41(5):833-45. doi: 10.1007/s00134-015-3725-1. Epub 2015 Apr 10.
10
Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit.组胺 2 受体拮抗剂与质子泵抑制剂对重症监护病房胃肠道出血和感染并发症的影响。
JAMA Intern Med. 2014 Apr;174(4):564-74. doi: 10.1001/jamainternmed.2013.14673.