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A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol.一项关于质子泵抑制剂与组胺-2受体阻滞剂在重症监护病房预防溃疡治疗中的群组随机、交叉、注册嵌入临床试验（PEPTIC研究）：研究方案。
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本文引用的文献

1
The implications of the PEPTIC trial for clinical practice.消化性溃疡试验对临床实践的启示。
Crit Care Resusc. 2020 Mar;22(1):4-5. doi: 10.51893/2020.1.ed1.
2
Could stress ulcer prophylaxis increase mortality in high-acuity patients?应激性溃疡预防措施会增加重症患者的死亡率吗？
Intensive Care Med. 2020 Apr;46(4):793-795. doi: 10.1007/s00134-020-05959-x. Epub 2020 Feb 19.
3
Learning health systems: an empowering agenda for low-income and middle-income countries.学习型卫生系统：低收入和中等收入国家的一项赋权议程。
Lancet. 2020 Feb 15;395(10223):476-477. doi: 10.1016/S0140-6736(19)33134-4.
4
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.质子泵抑制剂与组胺 2 受体拮抗剂预防应激性溃疡对接受有创机械通气的 ICU 患者院内死亡率的影响：PEPTIC 随机临床试验。
JAMA. 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190.
5
Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials.质子泵抑制剂与组胺-2受体阻滞剂用于危重症患者应激性溃疡预防：实用试验中的可解释性问题
JAMA. 2020 Feb 18;323(7):611-613. doi: 10.1001/jama.2019.22436.
6
How many times should a cluster randomized crossover trial cross over?整群随机交叉试验应该交叉多少次？
Stat Med. 2019 Nov 10;38(25):5021-5033. doi: 10.1002/sim.8349. Epub 2019 Sep 1.
7
A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol.一项关于质子泵抑制剂与组胺-2受体阻滞剂在重症监护病房预防溃疡治疗中的群组随机、交叉、注册嵌入临床试验（PEPTIC研究）：研究方案。
Crit Care Resusc. 2018 Sep;20(3):182-189.
8
Sample size calculations for cluster randomised crossover trials in Australian and New Zealand intensive care research.澳大利亚和新西兰重症监护研究中整群随机交叉试验的样本量计算
Crit Care Resusc. 2018 Jun;20(2):117-123.
9
Effect sizes in ongoing randomized controlled critical care trials.正在进行的随机对照重症监护试验中的效应大小。
Crit Care. 2017 Jun 5;21(1):132. doi: 10.1186/s13054-017-1726-x.
10
Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.危重症患者生存率的提高：大型随机对照试验比个性化医疗更有用吗？并非如此。
Intensive Care Med. 2016 Nov;42(11):1778-1780. doi: 10.1007/s00134-016-4482-5. Epub 2016 Sep 12.

Opportunities and challenges of clustering, crossing over, and using registry data in the PEPTIC trial.

作者信息

Young Paul J, Bagshaw Sean M, Forbes Andrew B, Nichol Alistair D, Wright Stephen E, Bellomo Rinaldo, van Haren Frank, Litton Edward, Webb Steve A

机构信息

Medical Research Institute of New Zealand, Wellington, New Zealand.

Department of Critical Care Medicine, University of Alberta Hospital, Alberta, Canada.

出版信息

Crit Care Resusc. 2020 Jun;22(2):105-109. doi: 10.51893/2020.2.ed2.

DOI:10.51893/2020.2.ed2
PMID:32389102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10692457/
Abstract
摘要