是时候直呼其名了？抗癫痫药物的情况
Time to Start Calling Things by Their Own Names? The Case for Antiseizure Medicines.
作者信息
French Jacqueline A, Perucca Emilio
机构信息
Department of Neurology, New York University School of Medicine, NY, USA.
Unit of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
出版信息
Epilepsy Curr. 2020 Mar;20(2):69-72. doi: 10.1177/1535759720905516. Epub 2020 Feb 20.
Abstract
Medicines currently used in the management of epilepsy have been developed to suppress seizures, and they have no known impact on the underlying disease. Using the term "antiepileptic" to describe these compounds is misleading because it suggests an action on the epilepsy itself. Pharmacological agents that have a merely symptomatic effect should be referred to as antiseizure medicines. Using appropriate terminology is especially important at a time innovative treatments targeting the development of epilepsy and its comorbidities are being actively pursued.
摘要
目前用于癫痫治疗的药物旨在抑制癫痫发作，且尚无证据表明它们对潜在疾病有影响。用“抗癫痫药”来描述这些化合物具有误导性，因为这意味着对癫痫本身有作用。仅具有对症治疗作用的药物应称为抗癫痫发作药物。在积极探索针对癫痫及其合并症的创新治疗方法的当下，使用恰当的术语尤为重要。
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2
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