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小儿癫痫的“观察等待”。我们的经验

['Wait and see' in paediatric epilepsy. Our experience].

作者信息

Salinas-Salvador B, Moreno-Sánchez A, Carmen-Marcén G, Molina-Herranz D, Lafuente-Hidalgo M, López-Pisón J

机构信息

HUMS. Hospital Universitario Miguel Servet, 50009 Zaragoza, España.

出版信息

Rev Neurol. 2023 Feb 1;76(3):83-89. doi: 10.33588/rn.7603.2022184.

Abstract

INTRODUCTION

Pharmacological treatment of epilepsy is not healing; it tries to avoid seizures, as far as possible, in children who probably would still have them.

PATIENTS AND METHODS

Our purpose is to analyse our experience with epileptic children and those who have a first non-symptomatic seizure without pharmacological treatment. Patients seen in a paediatric neurology consultation, from 2017 to 2021, who had suffered one or more acute non-symptomatic crises and who had not been treated pharmacologically, were analysed.

RESULTS

Sixty-five patients meet the selection criteria. Twenty-four patients had had a single crisis with a mean duration of 12 minutes (1-60). In 66.7% it was nocturnal. 41.7% presented pathological electroencephalogram, and 21% pathological findings in neuroimaging. The mean control time was 2.7 years (0.003-13.6 years). Forty-one presented more than one crisis, with a mean duration of nine minutes (1-60). Five patients presented more than 20 seizures, the rest between two and 17. Twenty-four (58.5%) presented only nocturnal seizures. An electroencephalogram was performed in all: epileptiform graphoelements in 63.4%; and neuroimaging in all: pathological in 4.9%. Mean control time was 3.8 years (0.01-9.1 years).

CONCLUSIONS

Seizure frequency, underlying pathology or test results should not be the only variables to take into consideration when starting antiepileptic drug treatment. The repercussion on their quality of life and neurodevelopment should prevail, agreeing on this decision with the parents.

摘要

引言

癫痫的药物治疗并非治愈;它旨在尽可能避免可能仍会发作的儿童出现癫痫发作。

患者与方法

我们的目的是分析我们对癫痫儿童以及首次出现非症状性癫痫发作且未接受药物治疗的儿童的经验。对2017年至2021年在儿科神经科门诊就诊、经历过一次或多次急性非症状性发作且未接受药物治疗的患者进行分析。

结果

65名患者符合入选标准。24名患者仅有一次发作,平均持续时间为12分钟(1 - 60分钟)。其中66.7%为夜间发作。41.7%的患者脑电图异常,21%的患者神经影像学检查有异常发现。平均控制时间为2.7年(0.003 - 13.6年)。41名患者发作不止一次,平均持续时间为9分钟(1 - 60分钟)。5名患者发作超过20次,其余患者发作2至17次。24名(58.5%)患者仅在夜间发作。所有患者均进行了脑电图检查:63.4%有癫痫样波形成分;所有患者均进行了神经影像学检查:4.9%有异常。平均控制时间为3.8年(0.01 - 9.1年)。

结论

在开始抗癫痫药物治疗时,癫痫发作频率、潜在病理或检查结果不应是唯一需要考虑的变量。应优先考虑对其生活质量和神经发育的影响,并与家长就这一决定达成一致。

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本文引用的文献

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[Considerations about treatment of childhood epilepsy with lamotrigine].[关于使用拉莫三嗪治疗儿童癫痫的考量]
J Healthc Qual Res. 2023 May-Jun;38(3):186-190. doi: 10.1016/j.jhqr.2022.08.009. Epub 2022 Oct 12.
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Antiepileptic Drug Treatment of Epilepsy in Children.儿童癫痫的抗癫痫药物治疗
Continuum (Minneap Minn). 2019 Apr;25(2):381-407. doi: 10.1212/CON.0000000000000712.
8
A Practical Guide to Treatment of Childhood Absence Epilepsy.儿童失神癫痫治疗实用指南。
Paediatr Drugs. 2019 Feb;21(1):15-24. doi: 10.1007/s40272-019-00325-x.
10
The management of epilepsy in children and adults.儿童和成人癫痫的管理。
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