Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Department of Internal Medicine, Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt.
Leuk Lymphoma. 2020 Jul;61(7):1645-1652. doi: 10.1080/10428194.2020.1728747. Epub 2020 Feb 20.
This study aimed to analyze the frequency of peripheral Mo-myeloid-derived suppressor cells (Mo-MDSCs) in newly diagnosed CLL patients and to correlate their level with other prognostic factors such as frequency of CD38 cells and ZAP-70 cells and with the clinical response and survival outcomes in these patients. Fifty CLL patients and 20 age-matched healthy controls were included in this study. Flow cytometric detection of ZAP 70, CD38, and Mo-MDSCs was done. Mo-MDSC levels wer significantly higher in CLL patients (27.51 ± 1.70) than healthy controls (16.79 ± 0.66; < .0001). Higher levels of Mo-MDSCs were detected in advanced Rai clinical staging than Stage I. Mo-MDSCs level was significantly correlated with the frequency of CD38 ( = 0.505; < .0001) and ZAP-70 cells ( = 0.421; < .0001). Higher levels of Mo-MDSCs predict poor survival in CLL patients with Mo-MDSCs levels <25% ( = 21) versus >25% ( = 29; log - Rank test, < .0001). In conclusion, Mo-MDSCs are correlated with tumor progression and a poor prognosis in CLL.
本研究旨在分析初诊 CLL 患者外周血髓系来源抑制细胞（Mo-MDSCs）的频率，并将其水平与其他预后因素（如 CD38 细胞和 ZAP-70 细胞的频率）以及这些患者的临床反应和生存结局相关联。本研究纳入了 50 例 CLL 患者和 20 名年龄匹配的健康对照者。采用流式细胞术检测 ZAP 70、CD38 和 Mo-MDSCs。CLL 患者的 Mo-MDSC 水平（27.51±1.70）明显高于健康对照组（16.79±0.66；<0.0001）。晚期 Rai 临床分期患者的 Mo-MDSC 水平高于Ⅰ期。Mo-MDSC 水平与 CD38 频率（ = 0.505；<0.0001）和 ZAP-70 细胞（ = 0.421；<0.0001）呈显著正相关。Mo-MDSC 水平较高预示着 CLL 患者的生存不良，Mo-MDSC 水平<25%（ = 21）的患者与>25%（ = 29）的患者相比（对数秩检验，<0.0001）。总之，Mo-MDSCs 与 CLL 中的肿瘤进展和不良预后相关。
