饮食丙烯酰胺与肾细胞癌之间无关联：一项更新的荟萃分析。
No association between dietary acrylamide and renal cell carcinoma: an updated meta-analysis.
机构信息
Department of Physical and Chemical Inspection, Wen Ling Institute For Food and Drug Control, Taizhou, China.
Public Health Section, Chengdu Shuangliu District Maternal and Child Health Hospital, Chengdu, China.
出版信息
J Sci Food Agric. 2020 May;100(7):3071-3077. doi: 10.1002/jsfa.10339. Epub 2020 Mar 2.
BACKGROUND
The relationship between dietary acrylamide intake and renal cell carcinoma risk is inconclusive. In consideration of the recent findings, we conducted an updated meta-analysis to assess the association between acrylamide intake and renal cell carcinoma risk.
RESULTS
PubMed, EMBASE, and Cochrane databases have been used to identify epidemiological studies on dietary acrylamide intake and renal cell carcinoma risk. This meta-analysis study included eight studies, 2843 cases, and 309 920 controls/participants. We performed meta-analyses to calculate the summary relative risk (RR) for the highest versus lowest intake of dietary acrylamide. No meaningful association was found for renal cell carcinoma; RR was 1.12 (95% confidence interval (CI): 0.97-1.28). Among participants who never smoked, no association was found between dietary acrylamide and renal cell carcinoma; the RR for highest versus lowest intake of dietary acrylamide was 1.11 (95% CI: 0.93-1.32).
CONCLUSION
This meta-analysis study indicates that dietary acrylamide is not related to the risk of renal cell carcinoma. © 2020 Society of Chemical Industry.
背景
饮食中丙烯酰胺摄入量与肾细胞癌风险之间的关系尚无定论。鉴于最近的研究结果，我们进行了一项更新的荟萃分析，以评估丙烯酰胺摄入与肾细胞癌风险之间的关系。
结果
我们使用 PubMed、EMBASE 和 Cochrane 数据库来确定关于饮食中丙烯酰胺摄入量与肾细胞癌风险的流行病学研究。这项荟萃分析研究包括 8 项研究，2843 例病例和 309920 例对照/参与者。我们进行了荟萃分析，以计算饮食中丙烯酰胺最高与最低摄入量的汇总相对风险（RR）。结果未发现肾细胞癌有显著相关性；RR 为 1.12（95%置信区间（CI）：0.97-1.28）。在从不吸烟的参与者中，饮食中丙烯酰胺与肾细胞癌之间没有关联；饮食中丙烯酰胺最高与最低摄入量的 RR 为 1.11（95%CI：0.93-1.32）。
结论
这项荟萃分析研究表明，饮食中丙烯酰胺与肾细胞癌风险无关。©2020 英国化学工业学会。
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