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野宽对 VMAT 计划质量的影响及半野方法的评估。

The impact of the field width on VMAT plan quality and the assessment of half field method.

机构信息

Department of Radiation Oncology, Faculty of Medicine, Inonu University, Malatya, Turkey.

出版信息

J Appl Clin Med Phys. 2020 Mar;21(3):115-122. doi: 10.1002/acm2.12834. Epub 2020 Feb 20.

Abstract

PURPOSE

The goal of this work is to investigate the field width dependence of the volumetric modulated arc therapy (VMAT) plan quality and to propose a half field method to irradiate large volumes effectively with VMAT.

MATERIALS AND METHODS

We compared four different VMAT methods; namely three full field (3ff), four full field (4ff), three half field (3hf), four half field (4hf). To evaluate the impact of the field width on VMAT plan quality, 12 different size PTVs were created in the virtual phantom and treatment plans generated for each PTV were compared. The effectiveness of our half field method was tested using computed tomography (CT) data of 10 nasopharyngeal carcinoma patients.

RESULTS

In the virtual phantom study, organs at risk (OAR) mean dose, the maximum point dose, and Homogeneity Index (HI) were found to be field width dependent. Conformation Number (CN) was not significantly affected. In the clinical study, 4hf plans obtained statistically significant dose reduction at brainstem (P < 0.001), right parotid (P = 0.034), oral cavity (P < 0.001), larynx (P = 0.003), cochlea (P = 0.017), lips (P = 0.024), and Body-PTV (P = 0.04) compared to 4ff plans.

CONCLUSION

Our results indicate that VMAT plan quality is dependent on the field width. Half field VMAT method, with the help of reduced field width, shows a clear advantage for the irradiation of large size targets compared to traditionally used full field VMAT plans.

摘要

目的

本研究旨在探讨容积旋转调强弧形治疗(VMAT)计划质量的射野宽度依赖性,并提出一种半野照射方法,以有效地用 VMAT 治疗大体积。

材料与方法

我们比较了四种不同的 VMAT 方法,即三个全野(3ff)、四个全野(4ff)、三个半野(3hf)、四个半野(4hf)。为了评估射野宽度对 VMAT 计划质量的影响,在虚拟体模中创建了 12 个不同大小的 PTV,并对每个 PTV 生成的治疗计划进行了比较。我们的半野方法的有效性是通过 10 例鼻咽癌患者的计算机断层扫描(CT)数据进行测试的。

结果

在虚拟体模研究中,发现危及器官(OAR)平均剂量、最大点剂量和均匀性指数(HI)与射野宽度有关。适形度指数(CN)没有受到显著影响。在临床研究中,4hf 计划在脑干(P < 0.001)、右腮腺(P = 0.034)、口腔(P < 0.001)、喉(P = 0.003)、耳蜗(P = 0.017)、唇(P = 0.024)和体部 PTV(P = 0.04)的剂量降低方面明显优于 4ff 计划。

结论

我们的结果表明,VMAT 计划质量取决于射野宽度。半野 VMAT 方法在减小射野宽度的帮助下,与传统使用的全野 VMAT 计划相比,对大体积靶区的照射具有明显优势。

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