Department of Histology and Embryology, Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
DNA Cell Biol. 2020 Aug;39(8):1401-1409. doi: 10.1089/dna.2019.5172. Epub 2020 Feb 20.
Polycystic ovary syndrome (PCOS) is one of the most common female reproductive metabolisms. It is an endocrine disease that affects reproductive women and often exhibits with hyperandrogenemia, insulin resistance (IR), low inflammation, and an increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular events such as hypertension and dyslipidemia in patients. However, the molecular mechanism of PCOS is still unclear. Recently, an increasing number of studies have shown that the oxidative stress induced by mitochondrial dysfunction has negative effects on IR, lipid metabolism, and follicular development, suggesting that mitochondrial dysfunction plays an essential role in the development of PCOS. Abnormal mitochondrial DNA copy number in patients with PCOS, and mitochondrial gene mutations, has been the focus of research in recent years, and functional mitochondrial diseases have been gradually accepted as a related factor in PCOS. This review is intended to summarize and discuss previous and recent studies and findings on the connections between mitochondrial dysfunction and PCOS.
多囊卵巢综合征（PCOS）是最常见的女性生殖代谢疾病之一。它是一种影响生殖女性的内分泌疾病，常表现为高雄激素血症、胰岛素抵抗（IR）、低度炎症和 2 型糖尿病、代谢综合征以及心血管事件（如高血压和血脂异常）风险增加。然而，PCOS 的分子机制尚不清楚。最近，越来越多的研究表明，线粒体功能障碍引起的氧化应激对 IR、脂代谢和卵泡发育有负面影响，提示线粒体功能障碍在 PCOS 的发生发展中起重要作用。PCOS 患者的线粒体 DNA 拷贝数异常和线粒体基因突变一直是近年来研究的焦点，功能性线粒体疾病已逐渐被认为是 PCOS 的相关因素。本综述旨在总结和讨论线粒体功能障碍与 PCOS 之间关系的既往和近期研究和发现。
