Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia.
Department of Medicine, School of Clinical Sciences, Monash Health, Monash University, Melbourne, Australia.
Arch Osteoporos. 2020 Feb 20;15(1):16. doi: 10.1007/s11657-020-0696-9.
This study reported that the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The magnitude of differences in areal and volumetric bone mineral density (aBMD, vBMD) between older and younger groups was similar.
Aging is strongly associated with bone loss, but little is known about magnitudes of differences in bone microarchitectures, aBMD, and vBMD from peak bone mass (PBM) to senescence. We aimed to describe differences in aBMD, vBMD, and bone microarchitecture parameters at the distal radius between older and young adults.
We compared 201 participants, aged 62-89 years (female 47%) and 196 participants, aged 24-28 years (female 38%). Bone microarchitecture parameters at distal radius were measured using high-resolution peripheral computed tomography (HRpQCT). aBMD was measured using dual-energy X-ray absorptiometry (DXA). Unpaired t tests and chi-square tests were used to compare differences in means and proportions as appropriate.
Older adults had thinner compact-appearing cortices with larger (cross-sectional area: outer 30.96 mm vs. 28.38 mm, inner 36.34 mm vs. 32.93 mm) and thicker (outer 0.57 mm vs. 0.54 mm, inner 0.71 mm vs. 0.65 mm) transitional zones compared with young adults (all p < 0.05). Cortical porosity was modestly higher in older adults than in young adults (54% vs. 49%, p < 0.001). The magnitude of the difference in hip aBMD between older and young adults was slightly lower than of total radial vBMD (- 0.51 SD vs. - 0.78 SD).
Compared with young adults at the time of PBM, the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The similar SD differences in aBMD and vBMD between older and younger groups suggest that the differences in bone area are not leading to major artefactual change in aBMD.
本研究报告称，老年人的过渡区增大，而外观紧凑的皮质区缩小，所有皮质亚区的孔隙率都增大。老年人和年轻人组之间骨矿物质密度（aBMD、vBMD）的面积和体积差异幅度相似。
衰老与骨量丢失密切相关，但对于从峰值骨量（PBM）到衰老期间骨微观结构、aBMD 和 vBMD 的差异幅度知之甚少。我们旨在描述桡骨远端的 aBMD、vBMD 和骨微观结构参数在老年人和年轻人之间的差异。
我们比较了 201 名年龄 62-89 岁（女性 47%）和 196 名年龄 24-28 岁（女性 38%）的参与者。使用高分辨率外周计算机断层扫描（HRpQCT）测量桡骨远端的骨微观结构参数。使用双能 X 射线吸收法（DXA）测量 aBMD。使用独立样本 t 检验和卡方检验比较均值和比例的差异，根据需要进行。
与年轻人相比，老年人的皮质外观更薄，过渡区更大（横截面面积：外 30.96mm 比 28.38mm，内 36.34mm 比 32.93mm）和更厚（外 0.57mm 比 0.54mm，内 0.71mm 比 0.65mm）（所有 p<0.05）。与年轻人相比，老年人的皮质孔隙率略高（54%比 49%，p<0.001）。老年人和年轻人之间髋部 aBMD 的差异幅度略低于桡骨总 vBMD 的差异幅度（-0.51 SD 比-0.78 SD）。
与 PBM 时的年轻人相比，老年人的过渡区增大，而外观紧凑的皮质区缩小，所有皮质亚区的孔隙率都增大。老年人和年轻人组之间 aBMD 和 vBMD 的 SD 差异相似，表明骨面积的差异不会导致 aBMD 的重大人为变化。
