Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, HobartHobart, TAS, 7000, Australia.
University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Arch Osteoporos. 2022 Dec 12;18(1):9. doi: 10.1007/s11657-022-01194-7.
Bone strength is important to prevent osteoporotic fractures and determined by bone mass and microarchitecture. This study suggests that having higher lean mass and lower fat mass, avoiding western dietary patterns, and improving steps per day may all be important for maintaining bone mass and microarchitecture in aging.
To describe associations between exposures of lean mass and fat mass, dietary patterns, serum 25-hydroxyvitamin D (25(OH)D), physical activity and grip strength, and bone outcome measures including bone mineral density and microarchitecture in older adults.
Data on 201 older adults (mean age 72 years, female 46% at 10.7-year follow-up (phase 4) from a population-based cohort study collected at baseline and follow-up at 2.6 (phase 2), 5.1 (phase 3), and 10.7 years (phase 4) were analyzed. Exposures were lean and fat mass, dietary patterns, physical activity (steps per day), serum 25(OH)D concentrations, and grip strength during follow-ups. Bone measures at phase 4 including areal bone mineral density (aBMD) at the spine, hip, and whole body by dual-energy X-ray absorptiometry, and radial cortical and trabecular bone microarchitecture by high-resolution peripheral computed tomography (HRpQCT). The cumulative average values of exposures were calculated. Multivariable linear regression was used to analyze associations between exposures and bone measures.
Lean mass was beneficially associated with the hip, spine, and total body aBMD, radial cortical and trabecular bone area, and trabecular number and separation (β ranged from - 0.39/standard deviation (SD) to 0.73/SD). Fat mass was detrimentally associated with radial compact cortical and inner transitional zone bone area, vBMD, and porosity (β ranged from - 0.21 to 0.22/SD). Western dietary pattern scores were detrimentally associated with radial total and cortical bone vBMD and porosity (β ranged from - 0.20 to 0.20/SD). Steps per day were beneficially associated with inner transitional zone area and thickness (β = 0.12/SD and 0.19/SD), but no other measures. Grip strength and serum 25(OH)D were not associated with any radial bone measures.
Lean mass was beneficially associated with aBMD, radial bone area, and trabecular bone microarchitecture. Fat mass had detrimental associations with radial bone area, vBMD, and porosity. A western dietary pattern was detrimental for radial bone microarchitecture while more steps per day (but not grip strength or 25(OH)D) appeared beneficial.
描述瘦体重和脂肪量、饮食模式、血清 25-羟维生素 D（25（OH）D）、体力活动和握力与骨密度和骨微结构等骨量结果指标之间的关联，这些指标在老年人中。
对来自一项基于人群的队列研究的 201 名老年人（平均年龄 72 岁，女性占 46%）进行分析，这些老年人在基线和 2.6 年（第 2 阶段）、5.1 年（第 3 阶段）和 10.7 年（第 4 阶段）进行随访。随访期间的暴露因素包括瘦体重和脂肪量、饮食模式、体力活动（每日步数）、血清 25（OH）D 浓度和握力。第 4 阶段的骨量测量指标包括双能 X 线吸收法测定的脊柱、髋部和全身的面积骨密度（aBMD），以及高分辨率外周计算机断层扫描（HRpQCT）测定的桡骨皮质和小梁骨微结构。计算暴露因素的累积平均值。采用多元线性回归分析暴露因素与骨量指标之间的关系。
瘦体重与髋部、脊柱和全身 aBMD、桡骨皮质和小梁骨面积以及小梁数量和分离度呈正相关（β值范围为-0.39/标准差（SD）至 0.73/SD）。脂肪量与桡骨皮质和内过渡区骨面积、vBMD 和孔隙度呈负相关（β值范围为-0.21 至 0.22/SD）。西方饮食模式评分与桡骨总骨和皮质骨 vBMD 及孔隙度呈负相关（β值范围为-0.20 至 0.20/SD）。每日步数与内过渡区面积和厚度呈正相关（β值分别为 0.12/SD 和 0.19/SD），但与其他指标无关。握力和血清 25（OH）D 与桡骨骨量无关。
瘦体重与 aBMD、桡骨骨面积和小梁骨微结构呈正相关。脂肪量与桡骨骨面积、vBMD 和孔隙度呈负相关。西方饮食模式对桡骨骨微结构不利，而每日步数增加（但握力和 25（OH）D 增加则无）似乎有益。
