Department of Gynecology and Obstetrics, Federal University of Uberlândia (UFU), Avenida Pará SN, Campus Umuarama, Uberlândia, Minas Gerais, 38400-902, Brazil.
Clinical Hospital, Federal University of Uberlândia - UFU, Avenida Pará SN, Campus Umuarama, Uberlândia, Minas Gerais, 38400-902, Brazil.
Curr Atheroscler Rep. 2020 Feb 19;22(3):13. doi: 10.1007/s11883-020-0830-6.
Cardiovascular and endothelial dysfunction is recognized nowadays as an important etiological factor contributing to the development of hypertensive disorders of pregnancy.
Preeclampsia is considered a specific disease of pregnancy, but recent theories suggest that women suffering from the condition have greater propensity to develop atherosclerosis, heart disease, and stroke over the years. It is possible that transient but severe endothelial dysfunction observed in preeclampsia potentiates a cascade of events that progresses to atherosclerosis. Preeclampsia offers a unique window of opportunity to identify maternal endothelial dysfunction and pre-existing cardiovascular disease. The placenta is closely involved in the onset of preeclampsia, but endothelial and cardiac vascular factors also play important causal roles in the development of hypertension during pregnancy. According to the data presented, it is clear that preeclampsia selects a group at high risk of development of atherosclerosis and at increased cardiovascular risk, as well as of stroke, in the decades following childbirth.
心血管和内皮功能障碍如今被认为是导致妊娠高血压疾病发展的一个重要病因。
子痫前期被认为是一种特定的妊娠疾病，但最近的理论表明，患有这种疾病的女性在多年后更有可能患上动脉粥样硬化、心脏病和中风。子痫前期中观察到的短暂但严重的内皮功能障碍可能会引发一系列进展为动脉粥样硬化的事件。子痫前期为识别母体内皮功能障碍和先前存在的心血管疾病提供了一个独特的机会。胎盘与子痫前期的发生密切相关，但内皮和心脏血管因素在妊娠期间高血压的发展中也起着重要的因果作用。根据所提供的资料，很明显，子痫前期会选择一群在分娩后几十年内发展为动脉粥样硬化和心血管风险增加以及中风风险增加的高风险人群。
