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Genome-Wide Association Study of Pain in Parkinson's Disease Implicates TRPM8 as a Risk Factor.

作者信息

Williams Nigel M, Hubbard Leon, Sandor Cynthia, Webber Caleb, Hendry Hannah, Lawton Michael, Carroll Camille, Chaudhuri K Ray, Morris Huw, Hu Michele T, Grosset Donald G, Kobylecki Christopher, Silverdale Monty

机构信息

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom.

Division of Neurology, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, United Kingdom.

出版信息

Mov Disord. 2020 Apr;35(4):705-707. doi: 10.1002/mds.28001. Epub 2020 Feb 20.

DOI:10.1002/mds.28001
PMID:32078185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7277058/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f4/7277058/5004f53e470b/MDS-35-705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f4/7277058/5004f53e470b/MDS-35-705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f4/7277058/5004f53e470b/MDS-35-705-g001.jpg

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本文引用的文献

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Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study.在一项基于英国大型人群的帕金森病研究中对孟德尔突变进行的遗传分析。
Brain. 2019 Sep 1;142(9):2828-2844. doi: 10.1093/brain/awz191.
2
Cannabinoid Ligands Targeting TRP Channels.靶向瞬时受体电位通道的大麻素配体
Front Mol Neurosci. 2019 Jan 15;11:487. doi: 10.3389/fnmol.2018.00487. eCollection 2018.
3
A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease.1957 名早期/中度帕金森病患者疼痛的详细临床研究。
一项针对疼痛、伤害感受、神经病变和疼痛治疗反应的全基因组关联研究的系统评价。
Pain. 2023 Sep 1;164(9):1891-1911. doi: 10.1097/j.pain.0000000000002910. Epub 2023 May 5.
4
Orofacial pain in 1916 patients with early or moderate Parkinson disease.1916例早期或中度帕金森病患者的口面部疼痛
Pain Rep. 2021 Apr 13;6(1):e923. doi: 10.1097/PR9.0000000000000923. eCollection 2021.
5
Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson's Disease: An Insight Into Role of Pharmacological Interventions.瞬时受体电位通道作为帕金森病治疗的新兴靶点：药理学干预作用的洞察
Front Cell Dev Biol. 2020 Nov 20;8:584513. doi: 10.3389/fcell.2020.584513. eCollection 2020.
Parkinsonism Relat Disord. 2018 Nov;56:27-32. doi: 10.1016/j.parkreldis.2018.06.001. Epub 2018 Jun 6.
4
Genetic studies of human neuropathic pain conditions: a review.人类神经性疼痛病症的遗传学研究：综述。
Pain. 2018 Mar;159(3):583-594. doi: 10.1097/j.pain.0000000000001099.
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Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine.用于治疗慢性疼痛和偏头痛的TRPM8拮抗剂的研发。
Pharmaceuticals (Basel). 2017 Mar 30;10(2):37. doi: 10.3390/ph10020037.
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The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog).新的NHGRI-EBI已发表全基因组关联研究目录（GWAS目录）。
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901. doi: 10.1093/nar/gkw1133. Epub 2016 Nov 29.
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