永不消逝：神经元 ATP 稳态的机制。

Not Fade Away: Mechanisms of Neuronal ATP Homeostasis.

机构信息

Department of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.

出版信息

Neuron. 2020 Feb 19;105(4):591-593. doi: 10.1016/j.neuron.2020.01.024.

DOI:10.1016/j.neuron.2020.01.024

PMID:32078791

Abstract

In this issue of Neuron, Ashrafi et al. (2020) identify a feedforward signaling mechanism that couples neuronal activity to the homeostatic maintenance of axonal and synaptic ATP production. This mechanism is achieved via changes in cytoplasmic calcium and activation of brain-specific, mitochondrial MICU3.

摘要

在本期《神经元》杂志中，Ashrafi 等人（2020 年）发现了一种前馈信号机制，该机制将神经元活动与轴突和突触 ATP 产生的稳态维持联系起来。这种机制是通过细胞质钙的变化和脑特异性线粒体 MICU3 的激活来实现的。