Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia.
Priority Research Centre Grow Up Well, Hunter Medical Research Institute, School of Medicine and Public Health, The University of Newcastle, New Lambton Heights, NSW 2305, Australia.
Nutrients. 2020 Feb 17;12(2):507. doi: 10.3390/nu12020507.
The prevalence of obesity in asthmatic children is high and is associated with worse clinical outcomes. We have previously reported that weight loss leads to improvements in lung function and asthma control in obese asthmatic children. The objectives of this secondary analysis were to examine: (1) changes in diet quality and (2) associations between the baseline subject characteristics and the degree of weight loss following the intervention. Twenty-eight obese asthmatic children, aged 8-17 years, completed a 10-week diet-induced weight loss intervention. Dietary intake, nutritional biomarkers, anthropometry, lung function, asthma control, and clinical outcomes were analysed before and after the intervention. Following the intervention, the body mass index (BMI) z-score decreased (Δ = 0.18 ± 0.04; < 0.001), %energy from protein increased (Δ = 4.3 ± 0.9%; = 0.002), and sugar intake decreased (Δ = 23.2 ± 9.3 g; = 0.025). Baseline lung function and physical activity level were inversely associated with Δ% fat mass. The ΔBMI z-score was negatively associated with physical activity duration at baseline. Dietary intervention is effective in achieving acute weight loss in obese asthmatic children, with significant improvements in diet quality and body composition. Lower lung function and physical engagement at baseline were associated with lesser weight loss, highlighting that subjects with these attributes may require greater support to achieve weight loss goals.
肥胖在哮喘儿童中较为普遍，与更差的临床结果相关。我们之前报道过，减肥可改善肥胖哮喘儿童的肺功能和哮喘控制。本二次分析的目的是检查：（1）饮食质量的变化；（2）干预前受试者特征与干预后体重减轻程度之间的关联。28 名 8-17 岁的肥胖哮喘儿童完成了为期 10 周的饮食诱导减肥干预。在干预前后分析了饮食摄入、营养生物标志物、人体测量学、肺功能、哮喘控制和临床结果。干预后，体重指数（BMI）z 评分降低（Δ=0.18±0.04；<0.001），蛋白质能量百分比增加（Δ=4.3±0.9%；=0.002），糖摄入量减少（Δ=23.2±9.3g；=0.025）。基线肺功能和体力活动水平与 Δ%脂肪量呈负相关。ΔBMI z 评分与基线时的体力活动持续时间呈负相关。饮食干预可有效实现肥胖哮喘儿童的急性体重减轻，饮食质量和身体成分显著改善。较低的基线肺功能和身体参与与较少的体重减轻相关，这表明具有这些特征的受试者可能需要更大的支持来实现减肥目标。
