Kong Jingwei, Yang Fan, Bai Minghua, Zong Yuhan, Li Zhuqing, Meng Xianghe, Zhao Xiaoshan, Wang Ji
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
Front Physiol. 2022 Aug 16;13:909209. doi: 10.3389/fphys.2022.909209. eCollection 2022.
The prevalence rates of obesity and its complications have increased dramatically worldwide. Obesity can lead to low-grade chronic systemic inflammation, which predisposes individuals to an increased risk of morbidity and mortality. Although obesity has received considerable interest in recent years, the essential role of obesity in asthma development has not been explored. Asthma is a common chronic inflammatory airway disease caused by various environmental allergens. Obesity is a critical risk factor for asthma exacerbation due to systemic inflammation, and obesity-related asthma is listed as an asthma phenotype. A suitable model can contribute to the understanding of the in-depth mechanisms of obese asthma. However, stable models for simulating clinical phenotypes and the impact of modeling on immune response vary across studies. Given that inflammation is one of the central mechanisms in asthma pathogenesis, this review will discuss immune responses in the airways of obese asthmatic mice on the basis of diverse modeling protocols.
肥胖及其并发症的患病率在全球范围内急剧上升。肥胖可导致低度慢性全身炎症，使个体患病和死亡风险增加。尽管近年来肥胖受到了广泛关注，但肥胖在哮喘发展中的关键作用尚未得到探讨。哮喘是一种由各种环境过敏原引起的常见慢性炎症性气道疾病。由于全身炎症，肥胖是哮喘加重的关键危险因素，肥胖相关哮喘被列为一种哮喘表型。合适的模型有助于深入了解肥胖性哮喘的机制。然而，模拟临床表型的稳定模型以及建模对免疫反应的影响在不同研究中各不相同。鉴于炎症是哮喘发病机制的核心机制之一，本综述将基于不同的建模方案，讨论肥胖哮喘小鼠气道中的免疫反应。
