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H19 lncRNA: Roles in tumorigenesis.H19 lncRNA：在肿瘤发生中的作用。
Biomed Pharmacother. 2020 Mar;123:109774. doi: 10.1016/j.biopha.2019.109774. Epub 2019 Dec 25.
2
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Exp Ther Med. 2019 Oct;18(4):2547-2553. doi: 10.3892/etm.2019.7850. Epub 2019 Aug 5.
3
Apatinib enhances chemosensitivity of gastric cancer to paclitaxel and 5-fluorouracil.阿帕替尼增强胃癌对紫杉醇和5-氟尿嘧啶的化疗敏感性。
Cancer Manag Res. 2019 May 29;11:4905-4915. doi: 10.2147/CMAR.S196372. eCollection 2019.
4
LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis.长链非编码 RNA MAFG-AS1 通过调控 miR-744-5p/MAFG 轴促进肺腺癌细胞的增殖。
Eur J Pharmacol. 2019 Sep 15;859:172465. doi: 10.1016/j.ejphar.2019.172465. Epub 2019 Jun 15.
5
LncRNA MAFG-AS1 promotes the aggressiveness of breast carcinoma through regulating miR-339-5p/MMP15.长链非编码 RNA MAFG-AS1 通过调控 miR-339-5p/MMP15 促进乳腺癌的侵袭转移。
Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2838-2846. doi: 10.26355/eurrev_201904_17561.
6
Long Chain Non-Coding RNA (lncRNA) HOTAIR Knockdown Increases miR-454-3p to Suppress Gastric Cancer Growth by Targeting STAT3/Cyclin D1.长链非编码 RNA（lncRNA）HOTAIR 敲低通过靶向 STAT3/细胞周期蛋白 D1 增加 miR-454-3p 抑制胃癌生长。
Med Sci Monit. 2019 Feb 27;25:1537-1548. doi: 10.12659/MSM.913087.
7
Long non-coding antisense RNA GAS6-AS1 supports gastric cancer progression via increasing GAS6 expression.长链非编码反义 RNA GAS6-AS1 通过增加 GAS6 的表达促进胃癌的进展。
Gene. 2019 May 15;696:1-9. doi: 10.1016/j.gene.2018.12.079. Epub 2019 Feb 5.
8
LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15.长链非编码 RNA MAFG-AS1 通过海绵吸附 MMP15 的 miR-339-5p 促进 NSCLC 细胞的迁移和侵袭。
Cell Biol Int. 2019 Apr;43(4):384-393. doi: 10.1002/cbin.11092. Epub 2019 Feb 6.
9
LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4.长链非编码 RNA MAFG-AS1 通过海绵吸附 miR-147b 和激活 NDUFA4 促进结直肠癌的进展。
Biochem Biophys Res Commun. 2018 Nov 17;506(1):251-258. doi: 10.1016/j.bbrc.2018.10.112. Epub 2018 Oct 19.
10
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.

MAFG-AS1 是胃癌临床进展和预后不良的新型临床生物标志物。

MAFG-AS1 is a novel clinical biomarker for clinical progression and unfavorable prognosis in gastric cancer.

机构信息

Department of Laboratory, Shandong University Hospital, Jinan, Shandong, China.

Department of Gastroenterology, Taishan Sanatorium of Shandong Province, Tai'an, Shandong, China.

出版信息

Cell Cycle. 2020 Mar;19(5):601-609. doi: 10.1080/15384101.2020.1728017. Epub 2020 Feb 20.

DOI:10.1080/15384101.2020.1728017
PMID:32079456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7100986/
Abstract

MAFG antisense 1 (MAFG-AS1) is recently identified as a novel lncRNA and serves as a tumor promoter in several types of human tumor. However, no prior study has been performed to evaluate the role of MAFG-AS1 in gastric cancer. In our study, we found MAFG-AS1 expression was increased in gastric cancer tissue samples compared with normal gastric mucosa tissue samples, and associated with poor overall survival in gastric cancer patients at The Cancer Genome Atlas database. Furthermore, we confirmed the clinical and prognostic significance of MAFG-AS1 in gastric cancer. We found gastric cancer tissues and cell lines had remarkably increased MAFG-AS1 expression in comparison to normal gastric mucosa tissues and normal human gastric epithelial cell line, and high MAFG-AS1 expression was positively associated with diffuse type, advanced clinical stage, extensive depth of invasion, more lymph node metastasis, and present distant metastasis in gastric cancer patients. Moreover, high MAFG-AS1 expression acted as one of the independent poor prognostic factors for overall survival in gastric cancer patients. The loss-of-function study showed knocking down MAFG-AS1 expression inhibited gastric cancer cell proliferation, migration and invasion . In conclusion, MAFG-AS1 is probable to be a valuable prognostic biomarker, and a novel potential target for gastric cancer.

摘要

MAFG 反义 1（MAFG-AS1）最近被鉴定为一种新型 lncRNA，在几种人类肿瘤中作为肿瘤促进物发挥作用。然而，之前没有人研究过 MAFG-AS1 在胃癌中的作用。在我们的研究中，我们发现与正常胃黏膜组织样本相比，胃癌组织样本中 MAFG-AS1 的表达增加，并且与癌症基因组图谱数据库中胃癌患者的总生存率降低相关。此外，我们还证实了 MAFG-AS1 在胃癌中的临床和预后意义。我们发现与正常胃黏膜组织和正常人类胃上皮细胞系相比，胃癌组织和细胞系中 MAFG-AS1 的表达显著增加，并且高 MAFG-AS1 表达与弥漫型、晚期临床分期、广泛的浸润深度、更多的淋巴结转移和目前的远处转移呈正相关。此外，高 MAFG-AS1 表达是胃癌患者总生存率的独立预后不良因素之一。功能丧失研究表明，下调 MAFG-AS1 表达抑制了胃癌细胞的增殖、迁移和侵袭。总之，MAFG-AS1 可能是一种有价值的预后生物标志物，也是胃癌的一个新的潜在治疗靶点。