Demirtas Atilim Armagan, Erdem Seyfettin, Karahan Mine, Keklikci Ugur
Department of Ophthalmology, Health Sciences University, Izmir Tepecik Training and Research Hospital, İzmir, Turkey.
Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Beyoglu Eye J. 2021 Jun 8;6(2):124-132. doi: 10.14744/bej.2021.66934. eCollection 2021.
The aim of this study was to investigate the magnitude of diurnal fluctuation in the superficial parafoveal vessel density (pfVD) and radial peripapillary capillary-peripapillary vessel density (RPC-ppVD) in exfoliative glaucoma (XFG) patients using optical coherence tomography angiography (OCTA) and to compare the findings with those of primary open-angle glaucoma (POAG) patients with glaucomatous damage of comparable severity.
A total of 50 patients with XFG and 48 with POAG were examined in this retrospective cross-sectional study. The OCTA readings and intraocular pressure (IOP) values were obtained at 9 am, 11 am, 2 pm, and 4 pm on the same day. The maximal change in the IOP and vessel density (VD) values was evaluated to determine the magnitude of diurnal variation.
No significant difference was found in the magnitude of the average diurnal superficial-pfVD, RPC-ppVD and IOP change between the XFG and POAG groups. Comparison of the diurnal variation of sub-sector VD revealed that the magnitude of the diurnal variation in the VD of the inferonasal peripapillary and superior parafoveal regions was greater in the XFG group than that of the POAG group (p=0.004 and p=0.021, respectively). Furthermore, the differences persisted after correcting for the confounding factors of IOP, mean deviation (MD), and global retinal nerve fiber layer (RNFL) values. The magnitude of the average superficial-pfVD and the average RPC-ppVD was not correlated with the MD, total ganglion cell complex, global RNFL, or the magnitude of IOP values in either group.
The eyes of XFG patients demonstrated more significant diurnal fluctuation in VD (including the superior superficial-pfVD as well as the inferonasal RPC-ppVD) when compared with POAG patients, despite no statistical significance between groups in the IOP variation.
本研究旨在利用光学相干断层扫描血管造影（OCTA）研究剥脱性青光眼（XFG）患者的浅表黄斑旁血管密度（pfVD）和放射状视乳头周围毛细血管-视乳头周围血管密度（RPC-ppVD）的昼夜波动幅度，并将结果与具有相似严重程度青光眼损害的原发性开角型青光眼（POAG）患者进行比较。
在这项回顾性横断面研究中，共检查了50例XFG患者和48例POAG患者。在同一天上午9点、11点、下午2点和4点获取OCTA读数和眼压（IOP）值。评估IOP和血管密度（VD）值的最大变化，以确定昼夜变化幅度。
XFG组和POAG组之间平均昼夜浅表pfVD、RPC-ppVD和IOP变化幅度无显著差异。子区域VD昼夜变化的比较显示，XFG组视乳头周围鼻下和黄斑上区域VD的昼夜变化幅度大于POAG组（分别为p = 0.004和p = 0.021）。此外，在校正IOP、平均偏差（MD）和全视网膜神经纤维层（RNFL）值的混杂因素后，差异仍然存在。两组中平均浅表pfVD和平均RPC-ppVD的幅度与MD、总神经节细胞复合体、全RNFL或IOP值的幅度均无相关性。
与POAG患者相比，XFG患者的眼睛VD昼夜波动更显著（包括浅表黄斑上pfVD以及视乳头周围鼻下RPC-ppVD），尽管两组之间IOP变化无统计学意义。
