Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Indoor Air. 2020 Jul;30(4):682-690. doi: 10.1111/ina.12657. Epub 2020 Mar 19.
About 339 million people worldwide are suffering from asthma. We aimed to investigate whether exposure to formaldehyde (FA) is associated with asthma, which could provide clues for preventive and mitigation actions. This article provides a systematic review and meta-analysis of observational studies to assess the association between indoor FA exposure and the risk of asthma in children and adults. An electronic search of PubMed, Embase, and Web of Science was performed to collect all relevant studies published before January 1, 2020, and a total of 13 papers were included in this meta-analysis. A random-effect model was conducted to calculate the pooled odds ratio (OR) between FA exposure and asthma. We found that each 10 µg/m increase in FA exposure was significantly associated with a 10% increase in the risk of asthma in children (OR = 1.10, 95% confidence interval = 1.00-1.21). We sorted the FA concentrations reported in the selected articles and categorized exposure variables into low (FA ≤ 22.5 µg/m ) and high exposure (FA > 22.5 µg/m ) according to the median concentration of FA. In the high-exposure adult group, FA exposure may also be associated with an increased risk of asthma (OR = 1.81, 95% CI = 1.18-2.78).
全球约有 3.39 亿人患有哮喘。我们旨在调查甲醛（FA）暴露是否与哮喘有关，这可为预防和缓解措施提供线索。本文对观察性研究进行了系统评价和荟萃分析，以评估室内 FA 暴露与儿童和成人哮喘风险之间的关系。通过电子检索 PubMed、Embase 和 Web of Science，收集了截至 2020 年 1 月 1 日之前发表的所有相关研究，共有 13 篇论文纳入本荟萃分析。采用随机效应模型计算 FA 暴露与哮喘之间的合并优势比（OR）。我们发现，FA 暴露每增加 10μg/m，儿童患哮喘的风险就会增加 10%（OR=1.10，95%置信区间=1.00-1.21）。我们对所选文章中报告的 FA 浓度进行了排序，并根据 FA 的中位数浓度将暴露变量分为低浓度（FA≤22.5μg/m）和高浓度（FA>22.5μg/m）。在高暴露的成年人群中，FA 暴露也可能与哮喘风险增加相关（OR=1.81，95%CI=1.18-2.78）。
