Cadete-Leite A, Tavares M A, Uylings H B, Paula-Barbosa M
Department of Anatomy, Porto Medical School, Portugal.
Brain Res. 1988 Nov 8;473(1):1-14. doi: 10.1016/0006-8993(88)90309-5.
The effects of chronic alcohol consumption (CAC) on the relative number of dentate gyrus granule cells and their dendritic trees, were studied in animals fed alcohol for 6, 12 and 18 months and in their respective controls. The granule cell density was estimated with the unbiased disector method. Following 6 months of alcohol consumption, the thickness of the dentate gyrus granular layer and the relative number of dentate granule cells were significantly decreased when compared with controls. The granule cell dendritic arborizations showed an increase of their dendritic extent in alcohol-treated rats. No significant differences were found in the density of dendritic spines between alcohol-fed and control animals. These results indicate the existence of hippocampal granule cell dendritic regrowth in alcohol-fed rats, probably occurring as a compensatory response to the granule cell deficit which follows the alcohol-induced granule cell degeneration. These degenerative and regenerative changes might have functional implications for the organization of the synaptic hippocampal circuitry after long periods of alcohol consumption.
研究了长期饮酒（CAC）对饮酒6个月、12个月和18个月的动物及其各自对照组齿状回颗粒细胞的相对数量及其树突的影响。采用无偏倚分割法估计颗粒细胞密度。饮酒6个月后，与对照组相比，齿状回颗粒层厚度和齿状颗粒细胞相对数量显著降低。在酒精处理的大鼠中，颗粒细胞树突分支的树突范围增加。在饮酒组和对照组动物之间，树突棘密度未发现显著差异。这些结果表明，饮酒大鼠海马颗粒细胞存在树突再生，这可能是对酒精诱导的颗粒细胞变性后颗粒细胞缺陷的一种代偿反应。这些退行性和再生性变化可能对长期饮酒后海马突触回路的组织具有功能意义。
