Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; Institute of Immunology, University of Science and Technology of China, Hefei, Anhui, China.
Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; Institute of Immunology, University of Science and Technology of China, Hefei, Anhui, China.
Adv Immunol. 2020;145:37-53. doi: 10.1016/bs.ai.2019.11.002. Epub 2019 Dec 9.
Natural killer (NK) cells are important innate effectors for their defense against pathogens and tumors without the need of prior sensitization. Along with the growing understanding of basic NK cell biology, it has been widely accepted that NK cells are a heterogeneous population of innate lymphoid cell (ILC) family. Apart from the conventional NK cell (cNK) subset that circulates throughout the body, some non-lymphoid tissues contain tissue-resident NK (trNK) cell subsets, and the composition of NK cell subsets varies greatly with different locations. Except for cNK cells, other ILCs are known as tissue-resident cells. In this review, we summarize the unique properties of trNK cells, discuss their lineage relationship with other ILCs, and highlight recent advances in our understanding of the functions of trNK cells and other ILCs.
自然杀伤 (NK) 细胞是防御病原体和肿瘤的重要先天效应器，无需预先致敏。随着对 NK 细胞基础生物学的认识不断深入，人们普遍认为 NK 细胞是先天淋巴细胞 (ILC) 家族的异质性群体。除了循环于全身的常规 NK 细胞 (cNK) 亚群外，一些非淋巴组织还含有组织驻留 NK (trNK) 细胞亚群，NK 细胞亚群的组成因位置而异而有很大差异。除了 cNK 细胞外，其他 ILC 被称为组织驻留细胞。在这篇综述中，我们总结了 trNK 细胞的独特特性，讨论了它们与其他 ILC 之间的谱系关系，并强调了我们对 trNK 细胞和其他 ILC 功能的理解的最新进展。
