Centre for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Immunology. 2013 Aug;139(4):416-27. doi: 10.1111/imm.12098.
Innate lymphoid cells (ILCs) is the collective term for a group of related innate lymphocytes, including natural killer (NK) cells and the more recently discovered non-NK ILCs, which all lack rearranged antigen receptors such as those expressed by T and B cells. Similar to NK cells, the newly discovered ILCs depend on the transcription factor Id2 and the common γ-chain of the interleukin-2 receptor for development. However, in contrast to NK cells, non-NK ILCs also require interleukin-7. In addition to the cytotoxic functions of NK cells, assuring protection against tumour development and viruses, new data indicate that ILCs contribute to a wide range of homeostatic and pathophysiological conditions in various organs via specialized cytokine production capabilities. Here we summarize current knowledge on ILCs with a particular emphasis on their tissue-specific effector functions, in the gut, liver, lungs and uterus. When possible, we try to highlight the role that these cells play in humans.
先天淋巴细胞 (ILCs) 是一组相关的先天淋巴细胞的统称，包括自然杀伤 (NK) 细胞和最近发现的非 NK ILCs，它们都缺乏重组抗原受体，如 T 和 B 细胞表达的受体。与 NK 细胞类似，新发现的 ILCs 依赖转录因子 Id2 和白细胞介素-2 受体的共同 γ 链发育。然而，与 NK 细胞不同的是，非 NK ILCs 还需要白细胞介素-7。除了 NK 细胞的细胞毒性功能，确保对肿瘤发展和病毒的保护外，新的数据表明，ILCs 通过专门的细胞因子产生能力，在各种器官的稳态和病理生理条件中发挥作用。在这里，我们总结了 ILCs 的最新知识，特别强调了它们在肠道、肝脏、肺部和子宫中的组织特异性效应功能。在可能的情况下，我们试图强调这些细胞在人类中的作用。
