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The Complex Role of Nociceptin Signaling in Stress: Clarity Through Neuroimaging?

作者信息

Piantadosi Sean C, Pizzagalli Diego A, Bruchas Michael R

机构信息

Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, Washington; Department of Anesthesiology, University of Washington, Seattle, Washington.

Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

出版信息

Biol Psychiatry. 2020 Mar 15;87(6):489-491. doi: 10.1016/j.biopsych.2020.01.002.

DOI:10.1016/j.biopsych.2020.01.002
PMID:32081252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7875195/
Abstract
摘要

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The Complex Role of Nociceptin Signaling in Stress: Clarity Through Neuroimaging?痛敏肽信号通路在应激中的复杂作用：通过神经影像学明晰？
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2
NOP Receptor Signaling Cascades.阿片受体信号级联反应。
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Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions.痛敏肽/孤啡肽与阿片肽在疼痛调节脑区显示出重叠分布，但并非共定位。
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Role of spinal opioid receptor on the antiallodynic effect of intrathecal nociceptin in neuropathic rat.鞘内给予孤啡肽对神经病理性痛大鼠镇痛作用中脊髓阿片受体的作用。
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Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus.孤啡肽诱导的豚鼠支气管速激肽能神经传递抑制
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[Molecular pharmacology and physiology of nociceptin].[孤啡肽的分子药理学与生理学]
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本文引用的文献

1
Acute Elevations in Cortisol Increase the In Vivo Binding of [C]NOP-1A to Nociceptin Receptors: A Novel Imaging Paradigm to Study the Interaction Between Stress- and Antistress-Regulating Neuropeptides.皮质醇水平的急性升高增加了 [C]NOP-1A 与孤啡肽受体的体内结合：一种研究应激和抗应激调节神经肽之间相互作用的新成像范式。
Biol Psychiatry. 2020 Mar 15;87(6):570-576. doi: 10.1016/j.biopsych.2019.09.013. Epub 2019 Sep 25.
2
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward.一个位于中脑腹侧被盖区的旁巨细胞核伤害感受神经元回路，它限制了对奖赏的动机。
Cell. 2019 Jul 25;178(3):653-671.e19. doi: 10.1016/j.cell.2019.06.034.
3
Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder.痛觉感受物质受体内体素受体减少与经历过性暴力的女大学生的韧性和恢复力有关：对创伤后应激障碍的治疗意义。
Biol Psychiatry. 2019 Jun 15;85(12):1056-1064. doi: 10.1016/j.biopsych.2019.02.017. Epub 2019 Apr 4.
4
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.孤啡肽/痛敏肽受体的结构、信号传导、配体、功能以及与阿片系统的相互作用
Pharmacol Rev. 2016 Apr;68(2):419-57. doi: 10.1124/pr.114.009209. Epub 2016 Mar 8.
5
Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors.束缚应激改变大鼠杏仁中央核中的孤啡肽/强啡肽和 CRF 系统：对焦虑样行为的意义。
J Neurosci. 2014 Jan 8;34(2):363-72. doi: 10.1523/JNEUROSCI.2400-13.2014.
6
The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.与肥胖、应激、焦虑、情绪和药物依赖有关的孤啡肽/Nociceptin（N/OFQ）的生物学。
Pharmacol Ther. 2014 Mar;141(3):283-99. doi: 10.1016/j.pharmthera.2013.10.011. Epub 2013 Nov 1.
7
Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography.正电子发射断层扫描成像脑孤啡肽/孤啡肽 FQ 肽（NOP）受体放射性配体的合成与评价。
J Med Chem. 2011 Apr 28;54(8):2687-700. doi: 10.1021/jm101487v. Epub 2011 Mar 25.
8
Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis.大鼠脑中孤啡肽/痛敏肽（N/OFQ）与促肾上腺皮质激素释放因子（CRF）之间的功能拮抗作用：终纹床核参与其中的证据
Psychopharmacology (Berl). 2008 Mar;196(4):523-31. doi: 10.1007/s00213-007-0985-7. Epub 2007 Nov 7.
9
Nociceptin/orphanin FQ content is decreased in forebrain neurones during acute stress.急性应激期间，前脑神经元中的痛敏肽/孤啡肽含量降低。
J Neuroendocrinol. 2003 Jan;15(1):69-74. doi: 10.1046/j.1365-2826.2003.00868.x.
10
Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more.孤啡肽/痛敏肽：在疼痛和镇痛中发挥作用，但远不止如此。
Trends Neurosci. 1998 May;21(5):215-21. doi: 10.1016/s0166-2236(97)01204-6.