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基于整合生物信息学分析的长链非编码 RNA H19 在脑胶质瘤中的表达及其预后价值。

Expression and prognostic value of long non-coding RNA H19 in glioma via integrated bioinformatics analyses.

机构信息

Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng 250000, Shandong Province, P.R. China.

Department of Chemotherapy, Chinese PLA General Hospital, Beijing 100036, P.R. China.

出版信息

Aging (Albany NY). 2020 Feb 20;12(4):3407-3430. doi: 10.18632/aging.102819.

DOI:10.18632/aging.102819
PMID:32081833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7066912/
Abstract

Numerous discoveries have elucidated that long noncoding RNAs (lncRNAs) play a critical role in cancer malignant progression. However, their potential involvement in gliomas remains to be explored. Herein, the expression level of lncRNA H19 in glioma tissues, and its relevance with clinical characteristics were analyzed through Oncomine. The results showed that H19 was highly expressed in glioma tissues and its expression increased with the increase of malignancy. Next, GTEx and TCGA data were downloaded for differently expressed genes (DEGs) identification, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, and the correlation analyses between H19 expression and clinic features. Radiation therapy had a good effect on glioblastoma multiforme (GBM), but didn't have a good effect on low grade glioma (LGG). Meanwhile, the expression level of H19 could act as an indicator molecule indicating the effect of radiotherapy. Finally, gene set enrichment analysis (GSEA) and immune infiltration analysis were conducted. It was found that H19 could affect the immune infiltration level of glioma through copy number variations, thus affecting the prognosis of glioma patients. Collectively, H19 may be involved in the occurrence and development of glioma, and has potential reference value for the relief and immunotherapy of glioma.

摘要

大量研究阐明长链非编码 RNA（lncRNA）在癌症恶性进展中发挥着关键作用。然而，其在神经胶质瘤中的潜在作用仍有待探索。本研究通过 Oncomine 分析了 lncRNA H19 在神经胶质瘤组织中的表达水平及其与临床特征的相关性。结果表明，H19 在神经胶质瘤组织中呈高表达，其表达水平随恶性程度的增加而升高。接下来，下载 GTEx 和 TCGA 数据以识别差异表达基因（DEGs），进行基因本体论（GO）和京都基因与基因组百科全书（KEGG）分析，并分析 H19 表达与临床特征之间的相关性。放射治疗对多形性胶质母细胞瘤（GBM）有较好的疗效，但对低级别神经胶质瘤（LGG）疗效不佳。同时，H19 的表达水平可以作为指示放射治疗效果的指标分子。最后，进行基因集富集分析（GSEA）和免疫浸润分析。结果发现，H19 可以通过拷贝数变异影响神经胶质瘤的免疫浸润水平，从而影响神经胶质瘤患者的预后。综上所述，H19 可能参与神经胶质瘤的发生发展，对神经胶质瘤的缓解和免疫治疗具有潜在的参考价值。

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