Sleep-Wake Disorders Unit, Soroka University Medical Center, P.O. Box 151, Beer-Sheva, 84105, Israel.
Shraga Segal Department of Microbiology and Immunology, Ben-Gurion University of the Negev, P.O. Box 105, Beer-Sheva, 84105, Israel.
Sci Rep. 2020 Feb 21;10(1):3206. doi: 10.1038/s41598-020-60226-9.
Upper airway obstruction can lead to growth retardation by unclear mechanisms. We explored the effect of upper airway obstruction in juvenile rats on whole-body energy balance, growth plate metabolism, and growth. We show that after seven weeks, obstructed animals' ventilation during room air breathing increased, and animals grew less due to abnormal growth plate metabolism. Increased caloric intake in upper airway-obstructed animals did not meet increased energy expenditure associated with increased work of breathing. Decreased whole-body energy balance induced hindrance of bone elongation following obstruction removal, and array pathways regulating growth plate development and marrow adiposity. This is the first study to show that rapidly growing animals cannot consume enough calories to maintain their energy homeostasis, leading to an impediment in growth in the effort to save energy.
上呼吸道阻塞可通过不明机制导致生长迟缓。我们探讨了幼年大鼠上呼吸道阻塞对全身能量平衡、生长板代谢和生长的影响。结果显示，七周后，阻塞组动物在室内空气呼吸时的通气量增加，且由于生长板代谢异常，动物生长较少。上呼吸道阻塞动物的热量摄入增加，但并不能满足与呼吸功增加相关的能量消耗增加。阻塞解除后，全身能量平衡的降低导致骨延长受阻，同时调节生长板发育和骨髓脂肪生成的多种途径也受到影响。这是首个证明快速生长的动物无法消耗足够的卡路里来维持其能量平衡，从而导致在努力节省能量的过程中生长受到阻碍的研究。
