Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
Oxid Med Cell Longev. 2020 Jan 27;2020:9761539. doi: 10.1155/2020/9761539. eCollection 2020.
It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus, innovative preventative programs and treatments are a necessity to fight this escalating pandemic disorder. Caveolin-1 (CAV1), an integral membrane protein, is the principal component of caveolae in membranes and is involved in multiple cellular functions such as endocytosis, cholesterol homeostasis, signal transduction, and mechanoprotection. Previous studies demonstrated that CAV1 is critical for insulin receptor-mediated signaling, insulin secretion, and potentially the development of insulin resistance. Here, we summarize the recent progress on the role of CAV1 in diabetes and diabetic complications.
据估计，2017 年全球有 4.51 亿人患有糖尿病。这些数字预计到 2045 年将增加到 6.93 亿；因此，需要创新的预防计划和治疗方法来应对这种不断升级的流行疾病。窖蛋白-1（CAV1）是一种完整的膜蛋白，是膜中的质膜小窝的主要成分，参与多种细胞功能，如内吞作用、胆固醇稳态、信号转导和机械保护。先前的研究表明，CAV1 对于胰岛素受体介导的信号转导、胰岛素分泌以及潜在的胰岛素抵抗的发展至关重要。在这里，我们总结了 CAV1 在糖尿病和糖尿病并发症中的作用的最新进展。
