Université Côte d'Azur, CoBTeK Laboratory, Nice, France.
Association IA (Alzheimer-Affect-Autism), Nice, France.
J Alzheimers Dis. 2020;74(2):669-677. doi: 10.3233/JAD-191282.
Apathy, a highly prevalent behavioral disorder in Alzheimer's disease and other related disorders, is currently assessed using clinical scales as it is for all neuropsychiatric disorders.
The aim of this study is to propose a new type of assessment using new technologies designed to assess loss of interest by a more implicit and indirect method.
The Interest Game is a form of interactive self-report, where categories of interests are presented in order to quantify them and identify the activities that constitute them. Two indices can be extracted, the number of categories and the number of activities selected. We compared the scores between three groups: Apathetic (A) and Non-Apathetic (NA) subjects (according to the Apathy Diagnostic Criteria) and controls with no objective cognitive impairment.
95 subjects were included. Results showed that subjects from the A group had significantly less interests (both categories and images selected) than the NA group. As expected, the control group selected a higher number of categories than the other groups. The diagnosis (minor or major neurocognitive disorder) and level of education had also a significant effect on the number of categories selected. Furthermore, subjects with major neurocognitive disorder (NCD) had significantly less interests than minor NCD group. The number of categories measure was more sensitive than the number of images selected.
The Interest Game is a promising tool to quantify and identify subject interests and differentiate between apathetic and non-apathetic subjects. Future studies should focus on including more apathetic subjects in the minor NCD group and validating this tool with the general population.
淡漠是阿尔茨海默病和其他相关疾病中一种普遍存在的行为障碍，目前像所有神经精神障碍一样，使用临床量表进行评估。
本研究旨在提出一种新的评估方法，利用旨在通过更隐式和间接的方法评估兴趣丧失的新技术。
趣味游戏是一种互动式自我报告形式，其中呈现出兴趣类别，以对其进行量化并确定构成它们的活动。可以提取两个指标，即类别数量和选择的活动数量。我们比较了三组的得分：淡漠（A）和非淡漠（NA）组（根据淡漠诊断标准）和无客观认知障碍的对照组。
共纳入 95 名受试者。结果表明，A 组受试者的兴趣（类别和所选图像）明显少于 NA 组。如预期的那样，对照组选择的类别数量高于其他组。诊断（轻度或重度神经认知障碍）和教育水平对所选类别的数量也有显著影响。此外，重度神经认知障碍（NCD）患者的兴趣明显少于轻度 NCD 组。类别数的测量比所选图像的数量更敏感。
趣味游戏是一种很有前途的工具，可以量化和识别受试者的兴趣，并区分淡漠和非淡漠的受试者。未来的研究应重点关注在轻度 NCD 组中纳入更多的淡漠患者，并使用一般人群验证该工具。
