与神经认知障碍相关的淡漠：最新进展与未来方向。
Apathy associated with neurocognitive disorders: Recent progress and future directions.
机构信息
Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Pharmacology/Toxicology, University of Toronto, Toronto, ON, Canada.
Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain; Department of Psychiatry & Research Institute Hospital, University Hospital 12 de Octubre, Madrid, Spain.
出版信息
Alzheimers Dement. 2017 Jan;13(1):84-100. doi: 10.1016/j.jalz.2016.05.008. Epub 2016 Jun 27.
INTRODUCTION
Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities.
METHODS
The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs.
RESULTS
Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches.
DISCUSSION
Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.
简介
冷漠在神经认知障碍（NCD）中很常见，如阿尔茨海默病和轻度认知障碍。尽管文献中对冷漠的定义不一致，但冷漠主要被定义为动机丧失和对日常活动的兴趣降低。
方法
阿尔茨海默病协会国际神经精神综合征专业兴趣小组（ISTAART）推进阿尔茨海默病研究和治疗（ISTAART）工作组审查了关于 NCD 中冷漠的最新研究。
结果
最近在三个与冷漠相关的领域取得了进展：（1）现象学，包括使用诊断标准和新的测量仪器，（2）神经生物学，包括神经影像学、神经病理学和生物标志物相关性，以及（3）干预措施，包括药物、非药物和非侵入性神经调节方法。
讨论
最近的进展证实，冷漠对患有重大 NCD 和轻度 NCD 的人有重大影响。因此，它是研究和干预的重要目标。
Zotero 插件