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Am J Respir Crit Care Med. 2020 Jun 15;201(12):1575-1578. doi: 10.1164/rccm.201912-2514LE.
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Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis.循环中 BMP10 和 BMP9 的减少以及内脂素的升高与肝硬化患者的疾病严重程度、失代偿和肺血管综合征有关。
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Bone morphogenetic protein 10 serves as a biomarker and a potential therapeutic target for endothelial dysfunction in endotoxin-induced acute lung injury.骨形态发生蛋白10作为内毒素诱导的急性肺损伤中内皮功能障碍的生物标志物和潜在治疗靶点。
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Bone morphogenetic protein 10 is increased in precapillary pulmonary hypertension patients.毛细血管前性肺动脉高压患者体内骨形态发生蛋白10水平升高。
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Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension.人类肝脏单核 RNA 测序提示 BMPR2、GDF15、精氨酸和雌激素与门脉性肺动脉高压有关。
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本文引用的文献

1
Characterization of Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.肺动脉高压中 BMP9 和 BMP10 突变和水平的特征。
Am J Respir Crit Care Med. 2020 Mar 1;201(5):575-585. doi: 10.1164/rccm.201906-1141OC.
2
Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension.骨形态发生蛋白 9 是门肺高血压的机制性生物标志物。
Am J Respir Crit Care Med. 2019 Apr 1;199(7):891-902. doi: 10.1164/rccm.201807-1236OC.
3
Pulse Oximetry Is Insensitive for Detection of Hepatopulmonary Syndrome in Patients Evaluated for Liver Transplantation.脉搏血氧仪对评估肝移植患者的肝肺综合征不敏感。
Hepatology. 2019 Jan;69(1):270-281. doi: 10.1002/hep.30139. Epub 2018 Dec 18.
4
A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma.骨形态发生蛋白 9（BMP9）和 BMP10 形成的异二聚体在血浆中提供了大多数 BMP 的生物学活性。
J Biol Chem. 2018 Jul 13;293(28):10963-10974. doi: 10.1074/jbc.RA118.002968. Epub 2018 May 22.
5
Clinical Impact of Intrapulmonary Vascular Dilatation in Candidates for Liver Transplant.肺血管扩张对肝移植候选者的临床影响。
Chest. 2018 Feb;153(2):414-426. doi: 10.1016/j.chest.2017.09.035. Epub 2017 Oct 5.
6
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.用骨形态发生蛋白9（BMP9）选择性增强内皮细胞中的骨形态发生蛋白受体II（BMPR-II）可逆转肺动脉高压。
Nat Med. 2015 Jul;21(7):777-85. doi: 10.1038/nm.3877. Epub 2015 Jun 15.
7
Pulmonary arteriovenous malformations after the superior cavopulmonary shunt: mechanisms and clinical implications.上腔静脉-肺动脉分流术后的肺动静脉畸形：机制及临床意义
Expert Rev Cardiovasc Ther. 2014 Jun;12(6):703-13. doi: 10.1586/14779072.2014.912132. Epub 2014 Apr 23.
8
Normal and abnormal pulmonary arteriovenous shunting: occurrence and mechanisms.正常与异常肺动静脉分流：发生率及机制
Cardiol Young. 2013 Oct;23(5):629-41. doi: 10.1017/S1047951113000140. Epub 2013 Mar 5.
9
BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain.BMP9 由肝细胞产生，主要以与其前肽结合的活性成熟形式在循环中。
Cell Mol Life Sci. 2012 Jan;69(2):313-24. doi: 10.1007/s00018-011-0751-1. Epub 2011 Jun 28.
10
Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates.肝肺综合征对肝移植候选者生活质量和生存的影响。
Gastroenterology. 2008 Oct;135(4):1168-75. doi: 10.1053/j.gastro.2008.06.038. Epub 2008 Jun 20.

BMP9/10 in Pulmonary Vascular Complications of Liver Disease.

作者信息

Rochon Elizabeth R, Krowka Michael J, Bartolome Sonja, Heresi Gustavo A, Bull Todd, Roberts Kari, Hemnes Anna, Forde Kimberly A, Krok Karen L, Patel Mamta, Lin Grace, McNeil Megan, Al-Naamani Nadine, Roman Beth L, Yu Paul B, Fallon Michael B, Gladwin Mark T, Kawut Steven M

机构信息

University of PittsburghPittsburgh, Pennsylvania.

Mayo ClinicRochester, Minnesota.

出版信息

Am J Respir Crit Care Med. 2020 Jun 15;201(12):1575-1578. doi: 10.1164/rccm.201912-2514LE.

DOI:10.1164/rccm.201912-2514LE
PMID:32083953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7301744/
Abstract
摘要