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揭示 BMP9 在肝脏疾病中的作用：发病机制和治疗潜力的深入了解。

Unveiling the Impact of BMP9 in Liver Diseases: Insights into Pathogenesis and Therapeutic Potential.

机构信息

Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.

Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.

出版信息

Biomolecules. 2024 Aug 15;14(8):1013. doi: 10.3390/biom14081013.

DOI:10.3390/biom14081013
PMID:39199400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11353080/
Abstract

Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor β(TGF-β) family. While initially recognized for their role in bone formation, BMPs have emerged as significant players in liver diseases. Among BMPs with various physiological activities, this comprehensive review aims to delve into the involvement of BMP9 specifically in liver diseases and provide insights into the complex BMP signaling pathway. Through an enhanced understanding of BMP9, we anticipate the discovery of new therapeutic options and potential strategies for managing liver diseases.

摘要

骨形态发生蛋白（BMPs）是一组属于转化生长因子 β（TGF-β）家族的生长因子。尽管最初因其在骨形成中的作用而被认识，但 BMPs 已成为肝脏疾病的重要参与者。在具有各种生理活性的 BMPs 中，本综述旨在深入探讨 BMP9 在肝脏疾病中的具体作用，并深入了解复杂的 BMP 信号通路。通过对 BMP9 的深入了解，我们预计将发现治疗肝脏疾病的新的治疗选择和潜在策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/2a55d557cd29/biomolecules-14-01013-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/82cf3d923beb/biomolecules-14-01013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/f6fb7ff758f5/biomolecules-14-01013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/68ac2e4fea97/biomolecules-14-01013-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/db37a4888559/biomolecules-14-01013-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/2a55d557cd29/biomolecules-14-01013-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/82cf3d923beb/biomolecules-14-01013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/f6fb7ff758f5/biomolecules-14-01013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/68ac2e4fea97/biomolecules-14-01013-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/db37a4888559/biomolecules-14-01013-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec54/11353080/2a55d557cd29/biomolecules-14-01013-g005.jpg

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Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome.BMP-9 信号通路紊乱损害肝肺综合征的肺血管完整性。
Am J Respir Crit Care Med. 2024 Sep 1;210(5):648-661. doi: 10.1164/rccm.202307-1289OC.
3
Elevated circulating BMP9 aggravates pulmonary angiogenesis in hepatopulmonary syndrome rats through ALK1-Endoglin-Smad1/5/9 signalling.
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Nutrients. 2025 Jan 31;17(3):547. doi: 10.3390/nu17030547.
升高的循环 BMP9 通过 ALK1-Endoglin-Smad1/5/9 信号加重肝肺综合征大鼠的肺血管生成。
Eur J Clin Invest. 2024 Aug;54(8):e14212. doi: 10.1111/eci.14212. Epub 2024 Apr 9.
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TGF-β signaling in health, disease, and therapeutics.TGF-β 信号在健康、疾病和治疗中的作用。
Signal Transduct Target Ther. 2024 Mar 22;9(1):61. doi: 10.1038/s41392-024-01764-w.
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