From the Pediatric Infectious and Tropical Diseases Department.
Immunology Department, Hospital La Paz, Madrid, Spain.
Pediatr Infect Dis J. 2020 Jul;39(7):620-623. doi: 10.1097/INF.0000000000002606.
We present a pediatric case series describing false-positive QuantiFERON-TB Gold In-tube (QFT-GIT) assay (QIAGEN, Germany) results observed in a tertiary hospital in Spain (2013-2018). During the study period, 7 of 737 test results were considered false-positives: 4 children with chronic medical conditions, 1 Mycobacterium lentiflavum lymphadenitis, 1 infant born to a mother with pulmonary tuberculosis, and 1 child exposed to a noninfectious tuberculosis patient. Data regarding interferon-gamma release assays false-positive results in children are scarce, and more studies are necessary to determine the rates of false-positive results in low-prevalence settings.
我们呈现了一系列儿科病例，描述了在西班牙一家三级医院（2013-2018 年）观察到的假阳性 QuantiFERON-TB Gold In-tube（QFT-GIT）检测结果（QIAGEN，德国）。在研究期间，737 次检测结果中有 7 次被认为是假阳性：4 名患有慢性疾病的儿童、1 例分枝杆菌 lentiflavum 淋巴结炎、1 例出生于患有肺结核母亲的婴儿和 1 例接触非传染性肺结核患者的儿童。关于儿童干扰素-γ释放检测假阳性结果的数据很少，需要更多的研究来确定在低流行地区假阳性结果的发生率。
