From the Infectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Déu Research Foundation, Barcelona, Spain.
Pediatric Infectious Diseases Unit, Gregorio Marañón Hospital, Madrid, Spain.
Pediatr Infect Dis J. 2021 Sep 1;40(9):e348-e351. doi: 10.1097/INF.0000000000003173.
In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.
在这项横断面研究中，对低流行国家 284 名临床或影像学疑似结核病的儿童和青少年进行了研究，QuantiFERON-TB Gold Plus 检测的特异性、敏感性、阳性预测值和阴性预测值分别为 91.5%、87.3%、86.4%和 91.2%。该检测的特异性高于同时进行的结核菌素皮肤试验，但与前一代干扰素-γ释放试验相似。
