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海绵可塑性过程中的铁代谢途径。

Iron metabolic pathways in the processes of sponge plasticity.

机构信息

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.

A.N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.

出版信息

PLoS One. 2020 Feb 21;15(2):e0228722. doi: 10.1371/journal.pone.0228722. eCollection 2020.

DOI:10.1371/journal.pone.0228722
PMID:32084159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7034838/
Abstract

The ability to regulate oxygen consumption evolved in ancestral animals and is intrinsically linked to iron metabolism. The iron pathways have been intensively studied in mammals, whereas data on distant invertebrates are limited. Sea sponges represent the oldest animal phylum and have unique structural plasticity and capacity to reaggregate after complete dissociation. We studied iron metabolic factors and their expression during reaggregation in the White Sea cold-water sponges Halichondria panicea and Halisarca dujardini. De novo transcriptomes were assembled using RNA-Seq data, and evolutionary trends were analyzed with bioinformatic tools. Differential expression during reaggregation was studied for H. dujardini. Enzymes of the heme biosynthesis pathway and transport globins, neuroglobin (NGB) and androglobin (ADGB), were identified in sponges. The globins mutate at higher evolutionary rates than the heme synthesis enzymes. Highly conserved iron-regulatory protein 1 (IRP1) presumably interacts with the iron-responsive elements (IREs) found in mRNAs of ferritin (FTH1) and a putative transferrin receptor NAALAD2. The reaggregation process is accompanied by increased expression of IRP1, the antiapoptotic factor BCL2, the inflammation factor NFκB (p65), FTH1 and NGB, as well as by an increase in mitochondrial density. Our data indicate a complex mechanism of iron regulation in sponge structural plasticity and help to better understand general mechanisms of morphogenetic processes in multicellular species.

摘要

调节耗氧量的能力在祖先动物中进化而来，与铁代谢有着内在的联系。铁代谢途径在哺乳动物中得到了深入研究，而关于遥远的无脊椎动物的数据则有限。海绵动物代表了最古老的动物门，具有独特的结构可塑性和在完全分离后重新聚集的能力。我们研究了铁代谢因子及其在白海冷水海绵 Halichondria panicea 和 Halisarca dujardini 重新聚集过程中的表达。使用 RNA-Seq 数据组装从头转录组，并使用生物信息学工具分析进化趋势。研究了 H. dujardini 在重新聚集过程中的差异表达。海绵动物中鉴定出血红素生物合成途径和转运珠蛋白（神经球蛋白[NGB]和雄激素球蛋白[ADGB]）的酶。珠蛋白的突变率高于血红素合成酶。高度保守的铁调节蛋白 1（IRP1）可能与铁反应元件（IREs）相互作用，这些 IREs存在于铁蛋白（FTH1）和假定的转铁蛋白受体 NAALAD2 的 mRNA 中。重新聚集过程伴随着 IRP1、抗凋亡因子 BCL2、炎症因子 NFκB（p65）、FTH1 和 NGB 的表达增加，以及线粒体密度的增加。我们的数据表明，海绵动物结构可塑性中铁调节的复杂机制有助于更好地理解多细胞物种形态发生过程的一般机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e8/7034838/61477894cd8c/pone.0228722.g010.jpg
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