大麻素CB2/Gi复合物的无核苷酸状态
The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex.
作者信息
Lynch Diane L, Hurst Dow P, Reggio Patricia H
机构信息
Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
出版信息
Cell. 2020 Feb 20;180(4):603-604. doi: 10.1016/j.cell.2020.01.034.
In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.
在本期《细胞》杂志中，两篇论文报道了大麻素受体CB2与Gi复合物的激动剂结合冷冻电镜结构。重要的是，这些结构不仅提供了有助于区分CB2与CB1配体结合的信息，还支持了G蛋白信号传导过程中无核苷酸状态的存在。
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