一种用于检测健康儿童和麻疹病毒感染患者血浆中循环α干扰素的灵敏放射免疫测定法。
A sensitive radioimmunoassay for circulating alpha-interferon in the plasma of healthy children and patients with measles virus infection.
作者信息
Shiozawa S, Yoshikawa N, Iijima K, Negishi K
机构信息
Department of Medicine, Kobe University School of Medicine, Japan.
出版信息
Clin Exp Immunol. 1988 Sep;73(3):366-9.
The mean circulating alpha-interferon of healthy children aged 2 to 13.5 yrs as measured by a radioimmunoassay was 0.119 +/- 0.031 ng/ml, which was significantly lower than that of young adults. Circulating alpha-interferon of children with measles virus infection aged 1 to 11 yrs, on their first visit to the hospital when they were fully symptomatic, was 0.095 +/- 0.035 ng/ml (n = 39). It was 0.105 +/- 0.070 ng/ml (n = 21) on their second visit, 7 to 10 days after their first visit when the patients were convalescent. The difference was statistically insignificant. It is concluded that immunoreactive circulating alpha-interferon is low in children and reaches maximum level in young adults, subsequently declining gradually with age. Immunoreactive circulating alpha-interferon, a possible reflection of endogenous alpha-interferon, does not change significantly by the infection of measles virus.
通过放射免疫测定法测得，2至13.5岁健康儿童的循环α干扰素平均值为0.119±0.031 ng/ml，显著低于年轻成年人。1至11岁麻疹病毒感染儿童首次因症状完全发作入院时，其循环α干扰素为0.095±0.035 ng/ml（n = 39）。首次入院7至10天后病情恢复期第二次入院时，该数值为0.105±0.070 ng/ml（n = 21）。差异无统计学意义。结论为，免疫反应性循环α干扰素在儿童中含量较低，在年轻成年人中达到最高水平，随后随年龄逐渐下降。免疫反应性循环α干扰素可能反映内源性α干扰素，麻疹病毒感染不会使其发生显著变化。
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