Griffin D E, Ward B J, Jauregui E, Johnson R T, Vaisberg A
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Clin Exp Immunol. 1990 Aug;81(2):218-24. doi: 10.1111/j.1365-2249.1990.tb03321.x.
Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 +/- 21 lytic units (LU)/10(7) cells) and 16 individuals with other infectious diseases (149 +/- 95 LU) and found it reduced compared with values for adults (375 +/- 70 LU; P less than 0.001) or children (300 +/- 73 LU, P less than 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 +/- 30 LU) and without (55 +/- 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.
据推测，自然杀伤细胞在宿主抗病毒防御中发挥着重要作用。我们检测了30例急性麻疹患者（73±21溶细胞单位（LU）/10⁷细胞）和16例其他传染病患者（149±95 LU）的自然杀伤细胞活性，发现其与未感染的成年人（375±70 LU；P<0.001）或儿童（300±73 LU，P<0.01）相比有所降低。在有并发症（84±30 LU）和无并发症（55±18 LU）的麻疹患者中均发现自然杀伤细胞活性降低，且在皮疹出现后至少3周内一直存在。细胞经体外白细胞介素-2暴露后活性增加。自然杀伤细胞活性降低在时间上与麻疹期间发生的细胞介导免疫的其他参数的抑制情况平行。
